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Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease

Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Und...

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Autores principales: O’Driscoll, Megan, Buddhari, Darunee, Huang, Angkana T., Waickman, Adam, Kaewhirun, Surachai, Iamsirithaworn, Sopon, Khampaen, Direk, Farmer, Aaron, Fernandez, Stefan, Rodriguez-Barraquer, Isabel, Srikiatkhachorn, Anon, Thomas, Stephen, Endy, Timothy, Rothman, Alan L., Anderson, Kathryn, Cummings, Derek A. T., Salje, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576102/
https://www.ncbi.nlm.nih.gov/pubmed/37774093
http://dx.doi.org/10.1073/pnas.2308221120
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author O’Driscoll, Megan
Buddhari, Darunee
Huang, Angkana T.
Waickman, Adam
Kaewhirun, Surachai
Iamsirithaworn, Sopon
Khampaen, Direk
Farmer, Aaron
Fernandez, Stefan
Rodriguez-Barraquer, Isabel
Srikiatkhachorn, Anon
Thomas, Stephen
Endy, Timothy
Rothman, Alan L.
Anderson, Kathryn
Cummings, Derek A. T.
Salje, Henrik
author_facet O’Driscoll, Megan
Buddhari, Darunee
Huang, Angkana T.
Waickman, Adam
Kaewhirun, Surachai
Iamsirithaworn, Sopon
Khampaen, Direk
Farmer, Aaron
Fernandez, Stefan
Rodriguez-Barraquer, Isabel
Srikiatkhachorn, Anon
Thomas, Stephen
Endy, Timothy
Rothman, Alan L.
Anderson, Kathryn
Cummings, Derek A. T.
Salje, Henrik
author_sort O’Driscoll, Megan
collection PubMed
description Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Understanding antibody-related mechanisms of enhanced infant dengue disease risk represents a significant challenge due to the dynamic nature of antibodies and their imperfect measurement processes. Further, key uncertainties exist regarding the impact of long-term shifts in birth rates, population-level infection risks, and maternal ages on the DENV immune landscape of newborns and their subsequent risks of severe dengue disease in infancy. Here, we analyze DENV antibody data from two infant cohorts (N = 142 infants with 605 blood draws) and 40 y of infant dengue hospitalization data from Thailand. We use mathematical models to reconstruct maternally derived antibody dynamics, accounting for discretized measurement processes and limits of assay detection. We then explore possible antibody-related mechanisms of enhanced infant dengue disease risk and their ability to reconstruct the observed age distribution of hospitalized infant dengue cases. We find that ADE mechanisms are best able to reconstruct the observed data. Finally, we describe how the shifting epidemiology of dengue in Thailand, combined with declining birth rates, have decreased the absolute risk of infant dengue disease by 88% over a 40-y period while having minimal impact on the mean age of infant hospitalized dengue disease.
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spelling pubmed-105761022023-10-15 Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease O’Driscoll, Megan Buddhari, Darunee Huang, Angkana T. Waickman, Adam Kaewhirun, Surachai Iamsirithaworn, Sopon Khampaen, Direk Farmer, Aaron Fernandez, Stefan Rodriguez-Barraquer, Isabel Srikiatkhachorn, Anon Thomas, Stephen Endy, Timothy Rothman, Alan L. Anderson, Kathryn Cummings, Derek A. T. Salje, Henrik Proc Natl Acad Sci U S A Biological Sciences Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Understanding antibody-related mechanisms of enhanced infant dengue disease risk represents a significant challenge due to the dynamic nature of antibodies and their imperfect measurement processes. Further, key uncertainties exist regarding the impact of long-term shifts in birth rates, population-level infection risks, and maternal ages on the DENV immune landscape of newborns and their subsequent risks of severe dengue disease in infancy. Here, we analyze DENV antibody data from two infant cohorts (N = 142 infants with 605 blood draws) and 40 y of infant dengue hospitalization data from Thailand. We use mathematical models to reconstruct maternally derived antibody dynamics, accounting for discretized measurement processes and limits of assay detection. We then explore possible antibody-related mechanisms of enhanced infant dengue disease risk and their ability to reconstruct the observed age distribution of hospitalized infant dengue cases. We find that ADE mechanisms are best able to reconstruct the observed data. Finally, we describe how the shifting epidemiology of dengue in Thailand, combined with declining birth rates, have decreased the absolute risk of infant dengue disease by 88% over a 40-y period while having minimal impact on the mean age of infant hospitalized dengue disease. National Academy of Sciences 2023-09-29 2023-10-10 /pmc/articles/PMC10576102/ /pubmed/37774093 http://dx.doi.org/10.1073/pnas.2308221120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biological Sciences
O’Driscoll, Megan
Buddhari, Darunee
Huang, Angkana T.
Waickman, Adam
Kaewhirun, Surachai
Iamsirithaworn, Sopon
Khampaen, Direk
Farmer, Aaron
Fernandez, Stefan
Rodriguez-Barraquer, Isabel
Srikiatkhachorn, Anon
Thomas, Stephen
Endy, Timothy
Rothman, Alan L.
Anderson, Kathryn
Cummings, Derek A. T.
Salje, Henrik
Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
title Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
title_full Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
title_fullStr Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
title_full_unstemmed Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
title_short Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
title_sort maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576102/
https://www.ncbi.nlm.nih.gov/pubmed/37774093
http://dx.doi.org/10.1073/pnas.2308221120
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