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Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease
Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Und...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576102/ https://www.ncbi.nlm.nih.gov/pubmed/37774093 http://dx.doi.org/10.1073/pnas.2308221120 |
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author | O’Driscoll, Megan Buddhari, Darunee Huang, Angkana T. Waickman, Adam Kaewhirun, Surachai Iamsirithaworn, Sopon Khampaen, Direk Farmer, Aaron Fernandez, Stefan Rodriguez-Barraquer, Isabel Srikiatkhachorn, Anon Thomas, Stephen Endy, Timothy Rothman, Alan L. Anderson, Kathryn Cummings, Derek A. T. Salje, Henrik |
author_facet | O’Driscoll, Megan Buddhari, Darunee Huang, Angkana T. Waickman, Adam Kaewhirun, Surachai Iamsirithaworn, Sopon Khampaen, Direk Farmer, Aaron Fernandez, Stefan Rodriguez-Barraquer, Isabel Srikiatkhachorn, Anon Thomas, Stephen Endy, Timothy Rothman, Alan L. Anderson, Kathryn Cummings, Derek A. T. Salje, Henrik |
author_sort | O’Driscoll, Megan |
collection | PubMed |
description | Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Understanding antibody-related mechanisms of enhanced infant dengue disease risk represents a significant challenge due to the dynamic nature of antibodies and their imperfect measurement processes. Further, key uncertainties exist regarding the impact of long-term shifts in birth rates, population-level infection risks, and maternal ages on the DENV immune landscape of newborns and their subsequent risks of severe dengue disease in infancy. Here, we analyze DENV antibody data from two infant cohorts (N = 142 infants with 605 blood draws) and 40 y of infant dengue hospitalization data from Thailand. We use mathematical models to reconstruct maternally derived antibody dynamics, accounting for discretized measurement processes and limits of assay detection. We then explore possible antibody-related mechanisms of enhanced infant dengue disease risk and their ability to reconstruct the observed age distribution of hospitalized infant dengue cases. We find that ADE mechanisms are best able to reconstruct the observed data. Finally, we describe how the shifting epidemiology of dengue in Thailand, combined with declining birth rates, have decreased the absolute risk of infant dengue disease by 88% over a 40-y period while having minimal impact on the mean age of infant hospitalized dengue disease. |
format | Online Article Text |
id | pubmed-10576102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-105761022023-10-15 Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease O’Driscoll, Megan Buddhari, Darunee Huang, Angkana T. Waickman, Adam Kaewhirun, Surachai Iamsirithaworn, Sopon Khampaen, Direk Farmer, Aaron Fernandez, Stefan Rodriguez-Barraquer, Isabel Srikiatkhachorn, Anon Thomas, Stephen Endy, Timothy Rothman, Alan L. Anderson, Kathryn Cummings, Derek A. T. Salje, Henrik Proc Natl Acad Sci U S A Biological Sciences Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Understanding antibody-related mechanisms of enhanced infant dengue disease risk represents a significant challenge due to the dynamic nature of antibodies and their imperfect measurement processes. Further, key uncertainties exist regarding the impact of long-term shifts in birth rates, population-level infection risks, and maternal ages on the DENV immune landscape of newborns and their subsequent risks of severe dengue disease in infancy. Here, we analyze DENV antibody data from two infant cohorts (N = 142 infants with 605 blood draws) and 40 y of infant dengue hospitalization data from Thailand. We use mathematical models to reconstruct maternally derived antibody dynamics, accounting for discretized measurement processes and limits of assay detection. We then explore possible antibody-related mechanisms of enhanced infant dengue disease risk and their ability to reconstruct the observed age distribution of hospitalized infant dengue cases. We find that ADE mechanisms are best able to reconstruct the observed data. Finally, we describe how the shifting epidemiology of dengue in Thailand, combined with declining birth rates, have decreased the absolute risk of infant dengue disease by 88% over a 40-y period while having minimal impact on the mean age of infant hospitalized dengue disease. National Academy of Sciences 2023-09-29 2023-10-10 /pmc/articles/PMC10576102/ /pubmed/37774093 http://dx.doi.org/10.1073/pnas.2308221120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biological Sciences O’Driscoll, Megan Buddhari, Darunee Huang, Angkana T. Waickman, Adam Kaewhirun, Surachai Iamsirithaworn, Sopon Khampaen, Direk Farmer, Aaron Fernandez, Stefan Rodriguez-Barraquer, Isabel Srikiatkhachorn, Anon Thomas, Stephen Endy, Timothy Rothman, Alan L. Anderson, Kathryn Cummings, Derek A. T. Salje, Henrik Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
title | Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
title_full | Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
title_fullStr | Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
title_full_unstemmed | Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
title_short | Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
title_sort | maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576102/ https://www.ncbi.nlm.nih.gov/pubmed/37774093 http://dx.doi.org/10.1073/pnas.2308221120 |
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