Oxidative regulation of TDP-43 self-association by a β-to-α conformational switch

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An evolutionarily conserved region of the TDP-43 low-complexity domain (LCD) twenty residues in length can adopt either an α-helical or β-strand conformation. When in the latter conformation, TDP-43 self-associates via the formation of a labile, cross-β structure. Self-association can be monitored v...

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Detalles Bibliográficos
Autores principales: Gu, Jinge, Zhou, Xiaoming, Sutherland, Lillian, Kato, Masato, Jaczynska, Klaudia, Rizo, Josep, McKnight, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576115/
https://www.ncbi.nlm.nih.gov/pubmed/37782781
http://dx.doi.org/10.1073/pnas.2311416120
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