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Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls

INTRODUCTION: The risk of cancer in patients with solitary colorectal juvenile polyps (JPs) is poorly investigated and several studies have reported polyps with dysplastic and adenomatous alterations. We aimed to investigate the long‐term risk of cancer and mortality in these patients by merging dat...

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Autores principales: Jelsig, Anne Marie, Wullum, Laus, Kuhlmann, Tine Plato, Ousager, Lilian Bomme, Burisch, Johan, Karstensen, John Gásdal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576602/
https://www.ncbi.nlm.nih.gov/pubmed/37498302
http://dx.doi.org/10.1002/ueg2.12441
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author Jelsig, Anne Marie
Wullum, Laus
Kuhlmann, Tine Plato
Ousager, Lilian Bomme
Burisch, Johan
Karstensen, John Gásdal
author_facet Jelsig, Anne Marie
Wullum, Laus
Kuhlmann, Tine Plato
Ousager, Lilian Bomme
Burisch, Johan
Karstensen, John Gásdal
author_sort Jelsig, Anne Marie
collection PubMed
description INTRODUCTION: The risk of cancer in patients with solitary colorectal juvenile polyps (JPs) is poorly investigated and several studies have reported polyps with dysplastic and adenomatous alterations. We aimed to investigate the long‐term risk of cancer and mortality in these patients by merging data from national registers and comparing them to a matched control cohort. MATERIALS AND METHODS: Patients with a solitary JP were identified in The Danish National Pathology Register and Data Bank (DNPR). The included patients were matched on sex, age, and place of birth with 50 controls. The groups were then analyzed for risk of cancer using the Danish Cancer Registry and mortality using the Danish Cause of Death Registry. RESULTS: We identified 1781 patients with solitary JPs and matched them with 83,713 controls. The mean follow‐up time was 7.65 years for cases and 7.36 years for controls. The risk of cancer, including colorectal cancer, did not differ for the two groups and when adjusting for sex and year of birth, the hazard ratio (HR) was 1.15 (confidence interval [CI] 95% 0.94–1.41, p = 0.162). There was no increased risk of death (HR: 1.07, CI 95% 0.88–1.30, p = 0.486). The risk did not differ for different age groups or sex. CONCLUSION: There is no increased risk of cancer or mortality for patients with solitary colorectal JPs. Thus, endoscopic follow‐up may be safely omitted in these patients.
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spelling pubmed-105766022023-10-15 Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls Jelsig, Anne Marie Wullum, Laus Kuhlmann, Tine Plato Ousager, Lilian Bomme Burisch, Johan Karstensen, John Gásdal United European Gastroenterol J Endoscopy INTRODUCTION: The risk of cancer in patients with solitary colorectal juvenile polyps (JPs) is poorly investigated and several studies have reported polyps with dysplastic and adenomatous alterations. We aimed to investigate the long‐term risk of cancer and mortality in these patients by merging data from national registers and comparing them to a matched control cohort. MATERIALS AND METHODS: Patients with a solitary JP were identified in The Danish National Pathology Register and Data Bank (DNPR). The included patients were matched on sex, age, and place of birth with 50 controls. The groups were then analyzed for risk of cancer using the Danish Cancer Registry and mortality using the Danish Cause of Death Registry. RESULTS: We identified 1781 patients with solitary JPs and matched them with 83,713 controls. The mean follow‐up time was 7.65 years for cases and 7.36 years for controls. The risk of cancer, including colorectal cancer, did not differ for the two groups and when adjusting for sex and year of birth, the hazard ratio (HR) was 1.15 (confidence interval [CI] 95% 0.94–1.41, p = 0.162). There was no increased risk of death (HR: 1.07, CI 95% 0.88–1.30, p = 0.486). The risk did not differ for different age groups or sex. CONCLUSION: There is no increased risk of cancer or mortality for patients with solitary colorectal JPs. Thus, endoscopic follow‐up may be safely omitted in these patients. John Wiley and Sons Inc. 2023-07-27 /pmc/articles/PMC10576602/ /pubmed/37498302 http://dx.doi.org/10.1002/ueg2.12441 Text en © 2023 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Endoscopy
Jelsig, Anne Marie
Wullum, Laus
Kuhlmann, Tine Plato
Ousager, Lilian Bomme
Burisch, Johan
Karstensen, John Gásdal
Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls
title Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls
title_full Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls
title_fullStr Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls
title_full_unstemmed Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls
title_short Cancer risk and mortality in patients with solitary juvenile polyps—A nationwide cohort study with matched controls
title_sort cancer risk and mortality in patients with solitary juvenile polyps—a nationwide cohort study with matched controls
topic Endoscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576602/
https://www.ncbi.nlm.nih.gov/pubmed/37498302
http://dx.doi.org/10.1002/ueg2.12441
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