Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine, is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its expression in T cells is disputed. Here, we demonstrate that induction of Arg1 expression is a key feature of lung CD4(+) T cells during mo...

Descripción completa

Detalles Bibliográficos
Autores principales: West, Erin E., Merle, Nicolas S., Kamiński, Marcin M., Palacios, Gustavo, Kumar, Dhaneshwar, Wang, Luopin, Bibby, Jack A., Overdahl, Kirsten, Jarmusch, Alan K., Freeley, Simon, Lee, Duck-Yeon, Thompson, J. Will, Yu, Zu-Xi, Taylor, Naomi, Sitbon, Marc, Green, Douglas R., Bohrer, Andrea, Mayer-Barber, Katrin D., Afzali, Behdad, Kazemian, Majid, Scholl-Buergi, Sabine, Karall, Daniela, Huemer, Martina, Kemper, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576612/
https://www.ncbi.nlm.nih.gov/pubmed/37572656
http://dx.doi.org/10.1016/j.immuni.2023.07.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576612/
https://www.ncbi.nlm.nih.gov/pubmed/37572656
http://dx.doi.org/10.1016/j.immuni.2023.07.014

Ejemplares similares