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Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC)
BACKGROUND: Only few ES-SCLC patients experience long-term survival benefit by maintenance IT. Adipokines-induced metabolic meta-inflammation has been related to enhanced responsiveness to IT in obese patients; however, their prognostic role in SCLC is currently controversial. METHODS: Pre-treatment...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576666/ https://www.ncbi.nlm.nih.gov/pubmed/37668709 http://dx.doi.org/10.1007/s00262-023-03533-0 |
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author | Vita, Emanuele Stefani, Alessio Piro, Geny Mastrantoni, Luca Cintoni, Marco Cicchetti, Giuseppe Sparagna, Ileana Monaca, Federico Horn, Guido Russo, Jacopo Barone, Diletta Di Salvatore, Mariantonietta Trisolini, Rocco Lococo, Filippo Mazzarella, Ciro Cancellieri, Alessandra Carbone, Carmine Larici, Anna Rita Mele, Maria Cristina Pilotto, Sara Milella, Michele Tortora, Giampaolo Bria, Emilio |
author_facet | Vita, Emanuele Stefani, Alessio Piro, Geny Mastrantoni, Luca Cintoni, Marco Cicchetti, Giuseppe Sparagna, Ileana Monaca, Federico Horn, Guido Russo, Jacopo Barone, Diletta Di Salvatore, Mariantonietta Trisolini, Rocco Lococo, Filippo Mazzarella, Ciro Cancellieri, Alessandra Carbone, Carmine Larici, Anna Rita Mele, Maria Cristina Pilotto, Sara Milella, Michele Tortora, Giampaolo Bria, Emilio |
author_sort | Vita, Emanuele |
collection | PubMed |
description | BACKGROUND: Only few ES-SCLC patients experience long-term survival benefit by maintenance IT. Adipokines-induced metabolic meta-inflammation has been related to enhanced responsiveness to IT in obese patients; however, their prognostic role in SCLC is currently controversial. METHODS: Pre-treatment CT scan was used for determining distribution of abdominal adiposity, and blood samples were collected at fasting for measuring glycemia, insulin, ghrelin, leptin and adipokines (TNF-α, IFN-γ, IL-6 and MCP-1). Patients with known history of DM type II or metabolic syndrome with HOMA index > 2.5 were considered insulin resistant (IR). RESULTS: In ES-SCLC pts receiving maintenance IT, increased leptin concentration and higher leptin/visceral adipose tissue (VAT) ratio were significantly associated with prolonged PFS. By applying a hierarchical clustering algorithm, we identified a cluster of patients characterized by higher leptin values and lower pro-inflammatory cytokines (TNF-α, IFN-γ and IL-6) who experienced longer PFS (13.2 vs 8.05 months; HR: 0.42 [0.18–0.93] p = 0.02) and OS (18.04 vs 12.09 mo; HR: 0.53 [0.25–1.29] p = 0.07). CONCLUSIONS: Adipokines can play a crucial role to determining effectiveness of anti-cancer immunotherapy. The role of metabolic immune dysfunctions needs further pre-clinical validation and is currently investigated in the larger prospective cohort. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00262-023-03533-0. |
format | Online Article Text |
id | pubmed-10576666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105766662023-10-16 Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) Vita, Emanuele Stefani, Alessio Piro, Geny Mastrantoni, Luca Cintoni, Marco Cicchetti, Giuseppe Sparagna, Ileana Monaca, Federico Horn, Guido Russo, Jacopo Barone, Diletta Di Salvatore, Mariantonietta Trisolini, Rocco Lococo, Filippo Mazzarella, Ciro Cancellieri, Alessandra Carbone, Carmine Larici, Anna Rita Mele, Maria Cristina Pilotto, Sara Milella, Michele Tortora, Giampaolo Bria, Emilio Cancer Immunol Immunother Research BACKGROUND: Only few ES-SCLC patients experience long-term survival benefit by maintenance IT. Adipokines-induced metabolic meta-inflammation has been related to enhanced responsiveness to IT in obese patients; however, their prognostic role in SCLC is currently controversial. METHODS: Pre-treatment CT scan was used for determining distribution of abdominal adiposity, and blood samples were collected at fasting for measuring glycemia, insulin, ghrelin, leptin and adipokines (TNF-α, IFN-γ, IL-6 and MCP-1). Patients with known history of DM type II or metabolic syndrome with HOMA index > 2.5 were considered insulin resistant (IR). RESULTS: In ES-SCLC pts receiving maintenance IT, increased leptin concentration and higher leptin/visceral adipose tissue (VAT) ratio were significantly associated with prolonged PFS. By applying a hierarchical clustering algorithm, we identified a cluster of patients characterized by higher leptin values and lower pro-inflammatory cytokines (TNF-α, IFN-γ and IL-6) who experienced longer PFS (13.2 vs 8.05 months; HR: 0.42 [0.18–0.93] p = 0.02) and OS (18.04 vs 12.09 mo; HR: 0.53 [0.25–1.29] p = 0.07). CONCLUSIONS: Adipokines can play a crucial role to determining effectiveness of anti-cancer immunotherapy. The role of metabolic immune dysfunctions needs further pre-clinical validation and is currently investigated in the larger prospective cohort. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00262-023-03533-0. Springer Berlin Heidelberg 2023-09-05 2023 /pmc/articles/PMC10576666/ /pubmed/37668709 http://dx.doi.org/10.1007/s00262-023-03533-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Vita, Emanuele Stefani, Alessio Piro, Geny Mastrantoni, Luca Cintoni, Marco Cicchetti, Giuseppe Sparagna, Ileana Monaca, Federico Horn, Guido Russo, Jacopo Barone, Diletta Di Salvatore, Mariantonietta Trisolini, Rocco Lococo, Filippo Mazzarella, Ciro Cancellieri, Alessandra Carbone, Carmine Larici, Anna Rita Mele, Maria Cristina Pilotto, Sara Milella, Michele Tortora, Giampaolo Bria, Emilio Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) |
title | Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) |
title_full | Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) |
title_fullStr | Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) |
title_full_unstemmed | Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) |
title_short | Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC) |
title_sort | leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (es-sclc) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576666/ https://www.ncbi.nlm.nih.gov/pubmed/37668709 http://dx.doi.org/10.1007/s00262-023-03533-0 |
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