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Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease
BACKGROUND: Sleep abnormalities have been reported in Charcot–Marie–Tooth disease (CMT), but data are scanty. We investigated their presence and correlation in a large CMT patients’ series. METHODS: Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were administered to CMT pat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576706/ https://www.ncbi.nlm.nih.gov/pubmed/37540277 http://dx.doi.org/10.1007/s00415-023-11911-y |
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author | Bellofatto, Marta Gentile, Luca Bertini, Alessandro Tramacere, Irene Manganelli, Fiore Fabrizi, Gian Maria Schenone, Angelo Santoro, Lucio Cavallaro, Tiziana Grandis, Marina Previtali, Stefano C. Scarlato, Marina Allegri, Isabella Padua, Luca Pazzaglia, Costanza Villani, Flavio Cavalca, Eleonora Saveri, Paola Quattrone, Aldo Valentino, Paola Tozza, Stefano Russo, Massimo Mazzeo, Anna Vita, Giuseppe Piacentini, Sylvie Didato, Giuseppe Pisciotta, Chiara Pareyson, Davide |
author_facet | Bellofatto, Marta Gentile, Luca Bertini, Alessandro Tramacere, Irene Manganelli, Fiore Fabrizi, Gian Maria Schenone, Angelo Santoro, Lucio Cavallaro, Tiziana Grandis, Marina Previtali, Stefano C. Scarlato, Marina Allegri, Isabella Padua, Luca Pazzaglia, Costanza Villani, Flavio Cavalca, Eleonora Saveri, Paola Quattrone, Aldo Valentino, Paola Tozza, Stefano Russo, Massimo Mazzeo, Anna Vita, Giuseppe Piacentini, Sylvie Didato, Giuseppe Pisciotta, Chiara Pareyson, Davide |
author_sort | Bellofatto, Marta |
collection | PubMed |
description | BACKGROUND: Sleep abnormalities have been reported in Charcot–Marie–Tooth disease (CMT), but data are scanty. We investigated their presence and correlation in a large CMT patients’ series. METHODS: Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were administered to CMT patients of the Italian registry and controls. ESS score > 10 indicated abnormal daytime somnolence, PSQI score > 5 bad sleep quality. We analyzed correlation with disease severity and characteristics, Hospital Anxiety and Depression Scale (HADS), Modified Fatigue Impact Scale (MFIS), Body Mass Index, drug use. RESULTS: ESS and PSQI questionnaires were filled by 257 and 253 CMT patients, respectively, and 58 controls. Median PSQI score was higher in CMT patients than controls (6 vs 4, p = 0.006), with no difference for ESS score. Abnormal somnolence and poor sleep quality occurred in 23% and 56% of patients; such patients had more frequently anxiety/depression, abnormal fatigue, and positive sensory symptoms than those with normal ESS/PSQI. Moreover, patients with PSQI score > 5 had more severe disease (median CMT Examination Score, CMTES, 8 vs 6, p = 0.006) and more frequent use of anxiolytic/antidepressant drugs (29% vs 7%, p < 0.001). CONCLUSIONS: Bad sleep quality and daytime sleepiness are frequent in CMT and correlated with anxiety, depression and fatigue, confirming that different components affect sleep. Sleep disorders, such as sleep apnea and restless leg syndrome, not specifically investigated here, are other factors known to impact on sleep quality and somnolence. CMT patients’ management must include sleep behavior assessment and evaluation of its correlated factors, including general distress and fatigue. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-023-11911-y. |
format | Online Article Text |
id | pubmed-10576706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105767062023-10-16 Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease Bellofatto, Marta Gentile, Luca Bertini, Alessandro Tramacere, Irene Manganelli, Fiore Fabrizi, Gian Maria Schenone, Angelo Santoro, Lucio Cavallaro, Tiziana Grandis, Marina Previtali, Stefano C. Scarlato, Marina Allegri, Isabella Padua, Luca Pazzaglia, Costanza Villani, Flavio Cavalca, Eleonora Saveri, Paola Quattrone, Aldo Valentino, Paola Tozza, Stefano Russo, Massimo Mazzeo, Anna Vita, Giuseppe Piacentini, Sylvie Didato, Giuseppe Pisciotta, Chiara Pareyson, Davide J Neurol Original Communication BACKGROUND: Sleep abnormalities have been reported in Charcot–Marie–Tooth disease (CMT), but data are scanty. We investigated their presence and correlation in a large CMT patients’ series. METHODS: Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were administered to CMT patients of the Italian registry and controls. ESS score > 10 indicated abnormal daytime somnolence, PSQI score > 5 bad sleep quality. We analyzed correlation with disease severity and characteristics, Hospital Anxiety and Depression Scale (HADS), Modified Fatigue Impact Scale (MFIS), Body Mass Index, drug use. RESULTS: ESS and PSQI questionnaires were filled by 257 and 253 CMT patients, respectively, and 58 controls. Median PSQI score was higher in CMT patients than controls (6 vs 4, p = 0.006), with no difference for ESS score. Abnormal somnolence and poor sleep quality occurred in 23% and 56% of patients; such patients had more frequently anxiety/depression, abnormal fatigue, and positive sensory symptoms than those with normal ESS/PSQI. Moreover, patients with PSQI score > 5 had more severe disease (median CMT Examination Score, CMTES, 8 vs 6, p = 0.006) and more frequent use of anxiolytic/antidepressant drugs (29% vs 7%, p < 0.001). CONCLUSIONS: Bad sleep quality and daytime sleepiness are frequent in CMT and correlated with anxiety, depression and fatigue, confirming that different components affect sleep. Sleep disorders, such as sleep apnea and restless leg syndrome, not specifically investigated here, are other factors known to impact on sleep quality and somnolence. CMT patients’ management must include sleep behavior assessment and evaluation of its correlated factors, including general distress and fatigue. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-023-11911-y. Springer Berlin Heidelberg 2023-08-04 2023 /pmc/articles/PMC10576706/ /pubmed/37540277 http://dx.doi.org/10.1007/s00415-023-11911-y Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Communication Bellofatto, Marta Gentile, Luca Bertini, Alessandro Tramacere, Irene Manganelli, Fiore Fabrizi, Gian Maria Schenone, Angelo Santoro, Lucio Cavallaro, Tiziana Grandis, Marina Previtali, Stefano C. Scarlato, Marina Allegri, Isabella Padua, Luca Pazzaglia, Costanza Villani, Flavio Cavalca, Eleonora Saveri, Paola Quattrone, Aldo Valentino, Paola Tozza, Stefano Russo, Massimo Mazzeo, Anna Vita, Giuseppe Piacentini, Sylvie Didato, Giuseppe Pisciotta, Chiara Pareyson, Davide Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease |
title | Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease |
title_full | Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease |
title_fullStr | Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease |
title_full_unstemmed | Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease |
title_short | Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease |
title_sort | daytime sleepiness and sleep quality in charcot–marie–tooth disease |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576706/ https://www.ncbi.nlm.nih.gov/pubmed/37540277 http://dx.doi.org/10.1007/s00415-023-11911-y |
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