Exploring potential anti-inflammatory effects of medicinal cannabis

PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive pro...

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Detalles Bibliográficos
Autores principales: Gurgenci, Taylan, Kijanka, Gregor, Greer, Ristan, Huggett, Georgie, Good, Phillip, Moniruzzaman, Md, Hardy, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576726/
https://www.ncbi.nlm.nih.gov/pubmed/37837446
http://dx.doi.org/10.1007/s00520-023-08069-8
Descripción
Sumario:PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. RESULTS: There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. CONCLUSION: We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. TRIAL REGISTRATION: ANZCTR 26180001220257, registered 20/07/2018. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-08069-8.

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