Exploring potential anti-inflammatory effects of medicinal cannabis

PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive pro...

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Autores principales: Gurgenci, Taylan, Kijanka, Gregor, Greer, Ristan, Huggett, Georgie, Good, Phillip, Moniruzzaman, Md, Hardy, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576726/
https://www.ncbi.nlm.nih.gov/pubmed/37837446
http://dx.doi.org/10.1007/s00520-023-08069-8
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author Gurgenci, Taylan
Kijanka, Gregor
Greer, Ristan
Huggett, Georgie
Good, Phillip
Moniruzzaman, Md
Hardy, Janet
author_facet Gurgenci, Taylan
Kijanka, Gregor
Greer, Ristan
Huggett, Georgie
Good, Phillip
Moniruzzaman, Md
Hardy, Janet
author_sort Gurgenci, Taylan
collection PubMed
description PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. RESULTS: There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. CONCLUSION: We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. TRIAL REGISTRATION: ANZCTR 26180001220257, registered 20/07/2018. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-08069-8.
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spelling pubmed-105767262023-10-16 Exploring potential anti-inflammatory effects of medicinal cannabis Gurgenci, Taylan Kijanka, Gregor Greer, Ristan Huggett, Georgie Good, Phillip Moniruzzaman, Md Hardy, Janet Support Care Cancer Research PURPOSE: Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. METHOD: Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. RESULTS: There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. CONCLUSION: We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. TRIAL REGISTRATION: ANZCTR 26180001220257, registered 20/07/2018. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00520-023-08069-8. Springer Berlin Heidelberg 2023-10-14 2023 /pmc/articles/PMC10576726/ /pubmed/37837446 http://dx.doi.org/10.1007/s00520-023-08069-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Gurgenci, Taylan
Kijanka, Gregor
Greer, Ristan
Huggett, Georgie
Good, Phillip
Moniruzzaman, Md
Hardy, Janet
Exploring potential anti-inflammatory effects of medicinal cannabis
title Exploring potential anti-inflammatory effects of medicinal cannabis
title_full Exploring potential anti-inflammatory effects of medicinal cannabis
title_fullStr Exploring potential anti-inflammatory effects of medicinal cannabis
title_full_unstemmed Exploring potential anti-inflammatory effects of medicinal cannabis
title_short Exploring potential anti-inflammatory effects of medicinal cannabis
title_sort exploring potential anti-inflammatory effects of medicinal cannabis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576726/
https://www.ncbi.nlm.nih.gov/pubmed/37837446
http://dx.doi.org/10.1007/s00520-023-08069-8
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