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Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients
Anomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail to assess the ischemic risk, calling for novel diagnostic approaches. To this aim, some recent studies propos...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576762/ https://www.ncbi.nlm.nih.gov/pubmed/37838795 http://dx.doi.org/10.1038/s41598-023-44568-8 |
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author | Ceserani, Valentina Lo Rito, Mauro Agnifili, Mauro Luca Pascaner, Ariel F. Rosato, Antonio Anglese, Serena Deamici, Miriam Negri, Jessica Corrado, Chiara Bedogni, Francesco Secchi, Francesco Lombardi, Massimo Auricchio, Ferdinando Frigiola, Alessandro Conti, Michele |
author_facet | Ceserani, Valentina Lo Rito, Mauro Agnifili, Mauro Luca Pascaner, Ariel F. Rosato, Antonio Anglese, Serena Deamici, Miriam Negri, Jessica Corrado, Chiara Bedogni, Francesco Secchi, Francesco Lombardi, Massimo Auricchio, Ferdinando Frigiola, Alessandro Conti, Michele |
author_sort | Ceserani, Valentina |
collection | PubMed |
description | Anomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail to assess the ischemic risk, calling for novel diagnostic approaches. To this aim, some recent studies propose to assess the coronary blood flow (CBF) in AAOCA by computational simulations but they are limited by the use of data from literature retrieved from normal subjects. To overcome this limitation and obtain a reliable assessment of CBF, we developed a fully patient-specific lumped parameter model based on clinical imaging and in-vivo data retrieved during invasive coronary functional assessment of subjects with AAOCA. In such a way, we can estimate the CBF replicating the two hemodynamic conditions in-vivo analyzed. The model can mimic the effective coronary behavior with high accuracy and could be a valuable tool to quantify CBF in AAOCA. It represents the first step required to move toward a future clinical application with the aim of improving patient care. The study was registered at Clinicaltrial.gov with (ID: NCT05159791, date 2021-12-16). |
format | Online Article Text |
id | pubmed-10576762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105767622023-10-16 Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients Ceserani, Valentina Lo Rito, Mauro Agnifili, Mauro Luca Pascaner, Ariel F. Rosato, Antonio Anglese, Serena Deamici, Miriam Negri, Jessica Corrado, Chiara Bedogni, Francesco Secchi, Francesco Lombardi, Massimo Auricchio, Ferdinando Frigiola, Alessandro Conti, Michele Sci Rep Article Anomalous aortic origin of the coronary artery (AAOCA) is a rare disease associated with sudden cardiac death, usually related to physical effort in young people. Clinical routine tests fail to assess the ischemic risk, calling for novel diagnostic approaches. To this aim, some recent studies propose to assess the coronary blood flow (CBF) in AAOCA by computational simulations but they are limited by the use of data from literature retrieved from normal subjects. To overcome this limitation and obtain a reliable assessment of CBF, we developed a fully patient-specific lumped parameter model based on clinical imaging and in-vivo data retrieved during invasive coronary functional assessment of subjects with AAOCA. In such a way, we can estimate the CBF replicating the two hemodynamic conditions in-vivo analyzed. The model can mimic the effective coronary behavior with high accuracy and could be a valuable tool to quantify CBF in AAOCA. It represents the first step required to move toward a future clinical application with the aim of improving patient care. The study was registered at Clinicaltrial.gov with (ID: NCT05159791, date 2021-12-16). Nature Publishing Group UK 2023-10-14 /pmc/articles/PMC10576762/ /pubmed/37838795 http://dx.doi.org/10.1038/s41598-023-44568-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ceserani, Valentina Lo Rito, Mauro Agnifili, Mauro Luca Pascaner, Ariel F. Rosato, Antonio Anglese, Serena Deamici, Miriam Negri, Jessica Corrado, Chiara Bedogni, Francesco Secchi, Francesco Lombardi, Massimo Auricchio, Ferdinando Frigiola, Alessandro Conti, Michele Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients |
title | Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients |
title_full | Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients |
title_fullStr | Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients |
title_full_unstemmed | Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients |
title_short | Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients |
title_sort | lumped-parameter model as a non-invasive tool to assess coronary blood flow in aaoca patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576762/ https://www.ncbi.nlm.nih.gov/pubmed/37838795 http://dx.doi.org/10.1038/s41598-023-44568-8 |
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