Cargando…

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

Mostrar otras versiones (1)

The TDP-43 proteinopathies, which include amyotrophic lateral sclerosis and frontotemporal dementia, are a devastating group of neurodegenerative disorders that are characterized by the mislocalization and aggregation of TDP-43. Here we demonstrate that RNA-targeting CRISPR effector proteins, a prog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeballos C., M. Alejandra, Moore, Hayden J., Smith, Tyler J., Powell, Jackson E., Ahsan, Najah S., Zhang, Sijia, Gaj, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576788/ https://www.ncbi.nlm.nih.gov/pubmed/37838698 http://dx.doi.org/10.1038/s41467-023-42147-z

Ejemplares similares

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins
por: Zeballos C, M. Alejandra, et al.
Publicado: (2023)

Molecular Neuropathology of TDP-43 Proteinopathies
por: Neumann, Manuela
Publicado: (2009)

Mechanisms and models of TDP-43 proteinopathies
por: Petrucelli, Leonard
Publicado: (2012)

Drosophila Answers to TDP-43 Proteinopathies
por: Romano, Maurizio, et al.
Publicado: (2012)

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets
por: Scotter, Emma L., et al.
Publicado: (2015)

The basis of clinicopathological heterogeneity in TDP-43 proteinopathy
por: Kawakami, Ito, et al.
Publicado: (2019)

Mechanisms of TDP-43 Proteinopathy Onset and Propagation
por: Chen, Han-Jou, et al.
Publicado: (2021)

Propagation of TDP-43 proteinopathy in neurodegenerative disorders
por: Keszycki, Rachel, et al.
Publicado: (2021)

TDP-43 Proteinopathy Specific Biomarker Development
por: Cordts, Isabell, et al.
Publicado: (2023)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
por: Atkinson, Rachel, et al.
Publicado: (2021)

Mitochondrion-Dependent Cell Death in TDP-43 Proteinopathies
por: Lucini, Chantal B., et al.
Publicado: (2021)

TDP-43 proteinopathy in Theiler’s murine encephalomyelitis virus infection
por: Masaki, Katsuhisa, et al.
Publicado: (2019)

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
por: Zhang, Jiasheng, et al.
Publicado: (2020)

TDP-43 proteinopathies: a new wave of neurodegenerative diseases
por: de Boer, Eva Maria Johanna, et al.
Publicado: (2021)

Functional implication of ubiquitinating and deubiquitinating mechanisms in TDP-43 proteinopathies
por: Tran, Non-Nuoc, et al.
Publicado: (2022)

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
por: Riku, Yuichi, et al.
Publicado: (2022)

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies
por: Young, Alexandra L, et al.
Publicado: (2023)

Understanding In Vitro Pathways to Drug Discovery for TDP-43 Proteinopathies
por: Cheng, Hei W. A., et al.
Publicado: (2022)

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies
por: Young, Alexandra L, et al.
Publicado: (2023)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
por: Necarsulmer, Julie C, et al.
Publicado: (2023)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies
por: Koopman, Mandy, et al.
Publicado: (2023)

Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications
por: Liu, Yu-Chih, et al.
Publicado: (2013)

Reviewing the Potential Links between Viral Infections and TDP-43 Proteinopathies
por: Rahic, Zerina, et al.
Publicado: (2023)

Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy
por: Matsukawa, Koji, et al.
Publicado: (2021)

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis
por: Smethurst, Phillip, et al.
Publicado: (2020)

Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
por: Godfrey, R. Keating, et al.
Publicado: (2023)

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice
por: Becker, Lindsay A., et al.
Publicado: (2017)

Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy()
por: Cortese, Andrea, et al.
Publicado: (2014)

Facial Onset Sensory and Motor Neuronopathy: Further Evidence for a TDP-43 Proteinopathy
por: Ziso, Besa, et al.
Publicado: (2015)

RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy
por: Chen, Han-Jou, et al.
Publicado: (2019)

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy
por: Liachko, Nicole F., et al.
Publicado: (2019)

Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions
por: Versluys, Lauren, et al.
Publicado: (2022)

Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
por: Khalil, Bilal, et al.
Publicado: (2022)

Restoring expression of Stathmin-2: a novel strategy to treat TDP-43 proteinopathies
por: Menge, Sonja, et al.
Publicado: (2023)

Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
por: Koga, Shunsuke, et al.
Publicado: (2023)

Parkin beyond Parkinson’s Disease—A Functional Meaning of Parkin Downregulation in TDP-43 Proteinopathies
por: Gaweda-Walerych, Katarzyna, et al.
Publicado: (2021)

Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production
por: Bjork, Reed T., et al.
Publicado: (2022)

Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates
por: Evangelista, Baggio A., et al.
Publicado: (2023)

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions
por: Watanabe, Ryohei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k9o8ekgvrse2iqo467igqsuvrh