Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

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The TDP-43 proteinopathies, which include amyotrophic lateral sclerosis and frontotemporal dementia, are a devastating group of neurodegenerative disorders that are characterized by the mislocalization and aggregation of TDP-43. Here we demonstrate that RNA-targeting CRISPR effector proteins, a prog...

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Detalles Bibliográficos
Autores principales: Zeballos C., M. Alejandra, Moore, Hayden J., Smith, Tyler J., Powell, Jackson E., Ahsan, Najah S., Zhang, Sijia, Gaj, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576788/
https://www.ncbi.nlm.nih.gov/pubmed/37838698
http://dx.doi.org/10.1038/s41467-023-42147-z
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