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Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde

To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents...

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Autores principales: Zhang, Zhijun, Yang, Yuan, Hu, Changjun, Zhang, Zaiqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576801/
https://www.ncbi.nlm.nih.gov/pubmed/37838763
http://dx.doi.org/10.1038/s41598-023-44788-y
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author Zhang, Zhijun
Yang, Yuan
Hu, Changjun
Zhang, Zaiqi
author_facet Zhang, Zhijun
Yang, Yuan
Hu, Changjun
Zhang, Zaiqi
author_sort Zhang, Zhijun
collection PubMed
description To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents of serum SOD, GR, MDA, DNA–protein crosslink (DPC), 8-hydroxydeoxyguanosine (8-OHDG) and DNA adduct were determined by ELISA. The results showed that there were statistically significant differences in the contents of SOD, GR and MDA among the four groups (P < 0.01). The activity of SOD and GR increased along with the increase of pachymaran dosage (SOD: r(s) = 0.912, P < 0.01; GR: r(s) = 0.857, P < 0.01), while the content of MDA showing a significant negative correlation (r(s) = − 0.893, P < 0.01). There were statistically significant differences in the levels of DPC, 8-OHDG and DNA adduct among the four groups (DPC and DNA adduct: P < 0.01, 8-OHDG: P < 0.05), the concentration decreased along with the increase of pachymaran dosage (DPC: r(s) = − 0.855, P < 0.01; 8-OHDG:r(s) = − 0.412, P < 0.05, DNA adduct: γ(s) = − 0.869, P < 0.01). It can be inferred that pachymaran can inhibit oxidative stress and DNA damage induced by formaldehyde with the dose–effect relationship.
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spelling pubmed-105768012023-10-16 Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde Zhang, Zhijun Yang, Yuan Hu, Changjun Zhang, Zaiqi Sci Rep Article To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents of serum SOD, GR, MDA, DNA–protein crosslink (DPC), 8-hydroxydeoxyguanosine (8-OHDG) and DNA adduct were determined by ELISA. The results showed that there were statistically significant differences in the contents of SOD, GR and MDA among the four groups (P < 0.01). The activity of SOD and GR increased along with the increase of pachymaran dosage (SOD: r(s) = 0.912, P < 0.01; GR: r(s) = 0.857, P < 0.01), while the content of MDA showing a significant negative correlation (r(s) = − 0.893, P < 0.01). There were statistically significant differences in the levels of DPC, 8-OHDG and DNA adduct among the four groups (DPC and DNA adduct: P < 0.01, 8-OHDG: P < 0.05), the concentration decreased along with the increase of pachymaran dosage (DPC: r(s) = − 0.855, P < 0.01; 8-OHDG:r(s) = − 0.412, P < 0.05, DNA adduct: γ(s) = − 0.869, P < 0.01). It can be inferred that pachymaran can inhibit oxidative stress and DNA damage induced by formaldehyde with the dose–effect relationship. Nature Publishing Group UK 2023-10-14 /pmc/articles/PMC10576801/ /pubmed/37838763 http://dx.doi.org/10.1038/s41598-023-44788-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Zhijun
Yang, Yuan
Hu, Changjun
Zhang, Zaiqi
Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
title Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
title_full Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
title_fullStr Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
title_full_unstemmed Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
title_short Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
title_sort effect of pachymaran on oxidative stress and dna damage induced by formaldehyde
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576801/
https://www.ncbi.nlm.nih.gov/pubmed/37838763
http://dx.doi.org/10.1038/s41598-023-44788-y
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