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Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde
To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576801/ https://www.ncbi.nlm.nih.gov/pubmed/37838763 http://dx.doi.org/10.1038/s41598-023-44788-y |
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author | Zhang, Zhijun Yang, Yuan Hu, Changjun Zhang, Zaiqi |
author_facet | Zhang, Zhijun Yang, Yuan Hu, Changjun Zhang, Zaiqi |
author_sort | Zhang, Zhijun |
collection | PubMed |
description | To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents of serum SOD, GR, MDA, DNA–protein crosslink (DPC), 8-hydroxydeoxyguanosine (8-OHDG) and DNA adduct were determined by ELISA. The results showed that there were statistically significant differences in the contents of SOD, GR and MDA among the four groups (P < 0.01). The activity of SOD and GR increased along with the increase of pachymaran dosage (SOD: r(s) = 0.912, P < 0.01; GR: r(s) = 0.857, P < 0.01), while the content of MDA showing a significant negative correlation (r(s) = − 0.893, P < 0.01). There were statistically significant differences in the levels of DPC, 8-OHDG and DNA adduct among the four groups (DPC and DNA adduct: P < 0.01, 8-OHDG: P < 0.05), the concentration decreased along with the increase of pachymaran dosage (DPC: r(s) = − 0.855, P < 0.01; 8-OHDG:r(s) = − 0.412, P < 0.05, DNA adduct: γ(s) = − 0.869, P < 0.01). It can be inferred that pachymaran can inhibit oxidative stress and DNA damage induced by formaldehyde with the dose–effect relationship. |
format | Online Article Text |
id | pubmed-10576801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105768012023-10-16 Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde Zhang, Zhijun Yang, Yuan Hu, Changjun Zhang, Zaiqi Sci Rep Article To further explore the pharmacological effect of pachymaran, this article studied the inhibition of pachymaran on oxidative stress and genetic damage induced by formaldehyde. 40 adult Kunming male mice were randomly divided into four groups with different interventions. One week later, the contents of serum SOD, GR, MDA, DNA–protein crosslink (DPC), 8-hydroxydeoxyguanosine (8-OHDG) and DNA adduct were determined by ELISA. The results showed that there were statistically significant differences in the contents of SOD, GR and MDA among the four groups (P < 0.01). The activity of SOD and GR increased along with the increase of pachymaran dosage (SOD: r(s) = 0.912, P < 0.01; GR: r(s) = 0.857, P < 0.01), while the content of MDA showing a significant negative correlation (r(s) = − 0.893, P < 0.01). There were statistically significant differences in the levels of DPC, 8-OHDG and DNA adduct among the four groups (DPC and DNA adduct: P < 0.01, 8-OHDG: P < 0.05), the concentration decreased along with the increase of pachymaran dosage (DPC: r(s) = − 0.855, P < 0.01; 8-OHDG:r(s) = − 0.412, P < 0.05, DNA adduct: γ(s) = − 0.869, P < 0.01). It can be inferred that pachymaran can inhibit oxidative stress and DNA damage induced by formaldehyde with the dose–effect relationship. Nature Publishing Group UK 2023-10-14 /pmc/articles/PMC10576801/ /pubmed/37838763 http://dx.doi.org/10.1038/s41598-023-44788-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Zhijun Yang, Yuan Hu, Changjun Zhang, Zaiqi Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde |
title | Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde |
title_full | Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde |
title_fullStr | Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde |
title_full_unstemmed | Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde |
title_short | Effect of pachymaran on oxidative stress and DNA damage induced by formaldehyde |
title_sort | effect of pachymaran on oxidative stress and dna damage induced by formaldehyde |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576801/ https://www.ncbi.nlm.nih.gov/pubmed/37838763 http://dx.doi.org/10.1038/s41598-023-44788-y |
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