SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease

Sirtuin 2 (SIRT2) has been proposed to have a central role on aging, inflammation, cancer and neurodegenerative diseases; however, its specific function remains controversial. Recent studies propose SIRT2 pharmacological inhibition as a therapeutic strategy for several neurodegenerative diseases inc...

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Detalles Bibliográficos
Autores principales: Sola-Sevilla, Noemi, Mesa-Lombardo, Alberto, Aleixo, Mikel, Expósito, Sara, Diaz-Perdigón, Teresa, Azqueta, Amaya, Zamani, Farzad, Suzuki, Takayoshi, Maioli, Silvia, Eroli, Francesca, Matton, Anna, Ramírez, Maria J., Solas, Maite, Tordera, Rosa M., Martín, Eduardo D., Puerta, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577113/
https://www.ncbi.nlm.nih.gov/pubmed/37698780
http://dx.doi.org/10.1007/s11481-023-10084-9

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