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The mechanism of ferroptosis and its related diseases
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, at...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577123/ https://www.ncbi.nlm.nih.gov/pubmed/37840106 http://dx.doi.org/10.1186/s43556-023-00142-2 |
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author | Feng, Shijian Tang, Dan Wang, Yichang Li, Xiang Bao, Hui Tang, Chengbing Dong, Xiuju Li, Xinna Yang, Qinxue Yan, Yun Yin, Zhijie Shang, Tiantian Zheng, Kaixuan Huang, Xiaofang Wei, Zuheng Wang, Kunjie Qi, Shiqian |
author_facet | Feng, Shijian Tang, Dan Wang, Yichang Li, Xiang Bao, Hui Tang, Chengbing Dong, Xiuju Li, Xinna Yang, Qinxue Yan, Yun Yin, Zhijie Shang, Tiantian Zheng, Kaixuan Huang, Xiaofang Wei, Zuheng Wang, Kunjie Qi, Shiqian |
author_sort | Feng, Shijian |
collection | PubMed |
description | Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations. |
format | Online Article Text |
id | pubmed-10577123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-105771232023-10-17 The mechanism of ferroptosis and its related diseases Feng, Shijian Tang, Dan Wang, Yichang Li, Xiang Bao, Hui Tang, Chengbing Dong, Xiuju Li, Xinna Yang, Qinxue Yan, Yun Yin, Zhijie Shang, Tiantian Zheng, Kaixuan Huang, Xiaofang Wei, Zuheng Wang, Kunjie Qi, Shiqian Mol Biomed Review Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations. Springer Nature Singapore 2023-10-16 /pmc/articles/PMC10577123/ /pubmed/37840106 http://dx.doi.org/10.1186/s43556-023-00142-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Feng, Shijian Tang, Dan Wang, Yichang Li, Xiang Bao, Hui Tang, Chengbing Dong, Xiuju Li, Xinna Yang, Qinxue Yan, Yun Yin, Zhijie Shang, Tiantian Zheng, Kaixuan Huang, Xiaofang Wei, Zuheng Wang, Kunjie Qi, Shiqian The mechanism of ferroptosis and its related diseases |
title | The mechanism of ferroptosis and its related diseases |
title_full | The mechanism of ferroptosis and its related diseases |
title_fullStr | The mechanism of ferroptosis and its related diseases |
title_full_unstemmed | The mechanism of ferroptosis and its related diseases |
title_short | The mechanism of ferroptosis and its related diseases |
title_sort | mechanism of ferroptosis and its related diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577123/ https://www.ncbi.nlm.nih.gov/pubmed/37840106 http://dx.doi.org/10.1186/s43556-023-00142-2 |
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