Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022

In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammal...

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Autores principales: Liang, Yuan, Hjulsager, Charlotte K., Jensen, Tim K., Hammer, Anne Sofie V., Ovesen, Maibritt T., Larsen, Lars E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577164/
https://www.ncbi.nlm.nih.gov/pubmed/37850154
http://dx.doi.org/10.1111/irv.13208
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author Liang, Yuan
Hjulsager, Charlotte K.
Jensen, Tim K.
Hammer, Anne Sofie V.
Ovesen, Maibritt T.
Larsen, Lars E.
author_facet Liang, Yuan
Hjulsager, Charlotte K.
Jensen, Tim K.
Hammer, Anne Sofie V.
Ovesen, Maibritt T.
Larsen, Lars E.
author_sort Liang, Yuan
collection PubMed
description In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals.
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spelling pubmed-105771642023-10-17 Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 Liang, Yuan Hjulsager, Charlotte K. Jensen, Tim K. Hammer, Anne Sofie V. Ovesen, Maibritt T. Larsen, Lars E. Influenza Other Respir Viruses Short Communications In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals. John Wiley and Sons Inc. 2023-10-15 /pmc/articles/PMC10577164/ /pubmed/37850154 http://dx.doi.org/10.1111/irv.13208 Text en © 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Liang, Yuan
Hjulsager, Charlotte K.
Jensen, Tim K.
Hammer, Anne Sofie V.
Ovesen, Maibritt T.
Larsen, Lars E.
Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
title Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
title_full Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
title_fullStr Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
title_full_unstemmed Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
title_short Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
title_sort characterization of high pathogenicity avian influenza h5nx viruses from a wild harbor seal and red foxes in denmark, 2021 and 2022
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577164/
https://www.ncbi.nlm.nih.gov/pubmed/37850154
http://dx.doi.org/10.1111/irv.13208
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