Cargando…
Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammal...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577164/ https://www.ncbi.nlm.nih.gov/pubmed/37850154 http://dx.doi.org/10.1111/irv.13208 |
_version_ | 1785121265327013888 |
---|---|
author | Liang, Yuan Hjulsager, Charlotte K. Jensen, Tim K. Hammer, Anne Sofie V. Ovesen, Maibritt T. Larsen, Lars E. |
author_facet | Liang, Yuan Hjulsager, Charlotte K. Jensen, Tim K. Hammer, Anne Sofie V. Ovesen, Maibritt T. Larsen, Lars E. |
author_sort | Liang, Yuan |
collection | PubMed |
description | In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals. |
format | Online Article Text |
id | pubmed-10577164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105771642023-10-17 Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 Liang, Yuan Hjulsager, Charlotte K. Jensen, Tim K. Hammer, Anne Sofie V. Ovesen, Maibritt T. Larsen, Lars E. Influenza Other Respir Viruses Short Communications In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals. John Wiley and Sons Inc. 2023-10-15 /pmc/articles/PMC10577164/ /pubmed/37850154 http://dx.doi.org/10.1111/irv.13208 Text en © 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communications Liang, Yuan Hjulsager, Charlotte K. Jensen, Tim K. Hammer, Anne Sofie V. Ovesen, Maibritt T. Larsen, Lars E. Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 |
title | Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 |
title_full | Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 |
title_fullStr | Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 |
title_full_unstemmed | Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 |
title_short | Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 |
title_sort | characterization of high pathogenicity avian influenza h5nx viruses from a wild harbor seal and red foxes in denmark, 2021 and 2022 |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577164/ https://www.ncbi.nlm.nih.gov/pubmed/37850154 http://dx.doi.org/10.1111/irv.13208 |
work_keys_str_mv | AT liangyuan characterizationofhighpathogenicityavianinfluenzah5nxvirusesfromawildharborsealandredfoxesindenmark2021and2022 AT hjulsagercharlottek characterizationofhighpathogenicityavianinfluenzah5nxvirusesfromawildharborsealandredfoxesindenmark2021and2022 AT jensentimk characterizationofhighpathogenicityavianinfluenzah5nxvirusesfromawildharborsealandredfoxesindenmark2021and2022 AT hammerannesofiev characterizationofhighpathogenicityavianinfluenzah5nxvirusesfromawildharborsealandredfoxesindenmark2021and2022 AT ovesenmaibrittt characterizationofhighpathogenicityavianinfluenzah5nxvirusesfromawildharborsealandredfoxesindenmark2021and2022 AT larsenlarse characterizationofhighpathogenicityavianinfluenzah5nxvirusesfromawildharborsealandredfoxesindenmark2021and2022 |