Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

A common pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the cytoplasmic mislocalization and aggregation of the DNA/RNA-binding protein TDP-43, but how loss of nuclear TDP-43 function contributes to ALS and FTD pathogenesis remains largely unknown. H...

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Detalles Bibliográficos
Autores principales: Fang, Minggang, Deibler, Sara K., Nana, Alissa L., Vatsavayai, Sarat C., Banday, Shahid, Zhou, You, Almeida, Sandra, Weiss, Alexandra, Brown, Robert H., Seeley, William W., Gao, Fen-Biao, Green, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577185/
https://www.ncbi.nlm.nih.gov/pubmed/37849894
http://dx.doi.org/10.3389/fnins.2023.1251228

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