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Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol

INTRODUCTION: Neurosurgery for brain tumors needs to find a complex balance between the effective removal of targeted tissue and the preservation of surrounding brain areas. Neuromodulation-induced cortical prehabilitation (NICP) is a promising strategy that combines temporary inhibition of critical...

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Autores principales: Boccuni, Leonardo, Abellaneda-Pérez, Kilian, Martín-Fernández, Jesús, Leno-Colorado, David, Roca-Ventura, Alba, Prats Bisbe, Alba, Buloz-Osorio, Edgar Antonio, Bartrés-Faz, David, Bargalló, Nuria, Cabello-Toscano, María, Pariente, José Carlos, Muñoz-Moreno, Emma, Trompetto, Carlo, Marinelli, Lucio, Villalba-Martinez, Gloria, Duffau, Hugues, Pascual-Leone, Álvaro, Tormos Muñoz, Josep María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577187/
https://www.ncbi.nlm.nih.gov/pubmed/37849833
http://dx.doi.org/10.3389/fneur.2023.1243857
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author Boccuni, Leonardo
Abellaneda-Pérez, Kilian
Martín-Fernández, Jesús
Leno-Colorado, David
Roca-Ventura, Alba
Prats Bisbe, Alba
Buloz-Osorio, Edgar Antonio
Bartrés-Faz, David
Bargalló, Nuria
Cabello-Toscano, María
Pariente, José Carlos
Muñoz-Moreno, Emma
Trompetto, Carlo
Marinelli, Lucio
Villalba-Martinez, Gloria
Duffau, Hugues
Pascual-Leone, Álvaro
Tormos Muñoz, Josep María
author_facet Boccuni, Leonardo
Abellaneda-Pérez, Kilian
Martín-Fernández, Jesús
Leno-Colorado, David
Roca-Ventura, Alba
Prats Bisbe, Alba
Buloz-Osorio, Edgar Antonio
Bartrés-Faz, David
Bargalló, Nuria
Cabello-Toscano, María
Pariente, José Carlos
Muñoz-Moreno, Emma
Trompetto, Carlo
Marinelli, Lucio
Villalba-Martinez, Gloria
Duffau, Hugues
Pascual-Leone, Álvaro
Tormos Muñoz, Josep María
author_sort Boccuni, Leonardo
collection PubMed
description INTRODUCTION: Neurosurgery for brain tumors needs to find a complex balance between the effective removal of targeted tissue and the preservation of surrounding brain areas. Neuromodulation-induced cortical prehabilitation (NICP) is a promising strategy that combines temporary inhibition of critical areas (virtual lesion) with intensive behavioral training to foster the activation of alternative brain resources. By progressively reducing the functional relevance of targeted areas, the goal is to facilitate resection with reduced risks of neurological sequelae. However, it is still unclear which modality (invasive vs. non-invasive neuromodulation) and volume of therapy (behavioral training) may be optimal in terms of feasibility and efficacy. METHODS AND ANALYSIS: Patients undertake between 10 and 20 daily sessions consisting of neuromodulation coupled with intensive task training, individualized based on the target site and neurological functions at risk of being compromised. The primary outcome of the proposed pilot, single-cohort trial is to investigate the feasibility and potential effectiveness of a non-invasive NICP protocol on neuroplasticity and post-surgical outcomes. Secondary outcomes investigating longitudinal changes (neuroimaging, neurophysiology, and clinical) are measured pre-NICP, post-NICP, and post-surgery. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Research Ethical Committee of Fundació Unió Catalana d'Hospitals (approval number: CEI 21/65, version 1, 13/07/2021). The results of the study will be submitted to a peer-reviewed journal and presented at scientific congresses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT05844605.
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spelling pubmed-105771872023-10-17 Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol Boccuni, Leonardo Abellaneda-Pérez, Kilian Martín-Fernández, Jesús Leno-Colorado, David Roca-Ventura, Alba Prats Bisbe, Alba Buloz-Osorio, Edgar Antonio Bartrés-Faz, David Bargalló, Nuria Cabello-Toscano, María Pariente, José Carlos Muñoz-Moreno, Emma Trompetto, Carlo Marinelli, Lucio Villalba-Martinez, Gloria Duffau, Hugues Pascual-Leone, Álvaro Tormos Muñoz, Josep María Front Neurol Neurology INTRODUCTION: Neurosurgery for brain tumors needs to find a complex balance between the effective removal of targeted tissue and the preservation of surrounding brain areas. Neuromodulation-induced cortical prehabilitation (NICP) is a promising strategy that combines temporary inhibition of critical areas (virtual lesion) with intensive behavioral training to foster the activation of alternative brain resources. By progressively reducing the functional relevance of targeted areas, the goal is to facilitate resection with reduced risks of neurological sequelae. However, it is still unclear which modality (invasive vs. non-invasive neuromodulation) and volume of therapy (behavioral training) may be optimal in terms of feasibility and efficacy. METHODS AND ANALYSIS: Patients undertake between 10 and 20 daily sessions consisting of neuromodulation coupled with intensive task training, individualized based on the target site and neurological functions at risk of being compromised. The primary outcome of the proposed pilot, single-cohort trial is to investigate the feasibility and potential effectiveness of a non-invasive NICP protocol on neuroplasticity and post-surgical outcomes. Secondary outcomes investigating longitudinal changes (neuroimaging, neurophysiology, and clinical) are measured pre-NICP, post-NICP, and post-surgery. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Research Ethical Committee of Fundació Unió Catalana d'Hospitals (approval number: CEI 21/65, version 1, 13/07/2021). The results of the study will be submitted to a peer-reviewed journal and presented at scientific congresses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT05844605. Frontiers Media S.A. 2023-10-02 /pmc/articles/PMC10577187/ /pubmed/37849833 http://dx.doi.org/10.3389/fneur.2023.1243857 Text en Copyright © 2023 Boccuni, Abellaneda-Pérez, Martín-Fernández, Leno-Colorado, Roca-Ventura, Prats Bisbe, Buloz-Osorio, Bartrés-Faz, Bargalló, Cabello-Toscano, Pariente, Muñoz-Moreno, Trompetto, Marinelli, Villalba-Martinez, Duffau, Pascual-Leone and Tormos Muñoz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Boccuni, Leonardo
Abellaneda-Pérez, Kilian
Martín-Fernández, Jesús
Leno-Colorado, David
Roca-Ventura, Alba
Prats Bisbe, Alba
Buloz-Osorio, Edgar Antonio
Bartrés-Faz, David
Bargalló, Nuria
Cabello-Toscano, María
Pariente, José Carlos
Muñoz-Moreno, Emma
Trompetto, Carlo
Marinelli, Lucio
Villalba-Martinez, Gloria
Duffau, Hugues
Pascual-Leone, Álvaro
Tormos Muñoz, Josep María
Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
title Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
title_full Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
title_fullStr Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
title_full_unstemmed Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
title_short Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
title_sort neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577187/
https://www.ncbi.nlm.nih.gov/pubmed/37849833
http://dx.doi.org/10.3389/fneur.2023.1243857
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