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Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine

The adaptive immune responses induced by inactivated COVID-19 vaccine has been extensively studied. However, few studies have analyzed the impact of COVID-19 vaccination on innate immune cells. Here in this study, we recruited 62 healthcare workers who received three doses of CoronaVac vaccine and l...

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Autores principales: Cao, Cheng, Jiang, Junfeng, Liu, Min, Dai, Yaping, Chang, Tianzhi, Ji, Tuo, Gong, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577214/
https://www.ncbi.nlm.nih.gov/pubmed/37849746
http://dx.doi.org/10.3389/fimmu.2023.1277831
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author Cao, Cheng
Jiang, Junfeng
Liu, Min
Dai, Yaping
Chang, Tianzhi
Ji, Tuo
Gong, Fang
author_facet Cao, Cheng
Jiang, Junfeng
Liu, Min
Dai, Yaping
Chang, Tianzhi
Ji, Tuo
Gong, Fang
author_sort Cao, Cheng
collection PubMed
description The adaptive immune responses induced by inactivated COVID-19 vaccine has been extensively studied. However, few studies have analyzed the impact of COVID-19 vaccination on innate immune cells. Here in this study, we recruited 62 healthcare workers who received three doses of CoronaVac vaccine and longitudinally profiled the alterations of peripheral monocytes and NK cells during vaccination. The results showed that both the monocyte and NK cell subsets distribution were altered, although the frequencies of the total monocyte and NK cells remained stable during the vaccination. Additionally, we found that both the 2(nd) and 3(rd) dose of CoronaVac vaccination elicited robust IFN-γ-producing NK cell response. Our data provided necessary insights on innate immune responses in the context of three homologous CoronaVac dose vaccination, and supplied immunological basis for the future design of inactivated vaccines against SARS-CoV-2 or other viruses.
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spelling pubmed-105772142023-10-17 Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine Cao, Cheng Jiang, Junfeng Liu, Min Dai, Yaping Chang, Tianzhi Ji, Tuo Gong, Fang Front Immunol Immunology The adaptive immune responses induced by inactivated COVID-19 vaccine has been extensively studied. However, few studies have analyzed the impact of COVID-19 vaccination on innate immune cells. Here in this study, we recruited 62 healthcare workers who received three doses of CoronaVac vaccine and longitudinally profiled the alterations of peripheral monocytes and NK cells during vaccination. The results showed that both the monocyte and NK cell subsets distribution were altered, although the frequencies of the total monocyte and NK cells remained stable during the vaccination. Additionally, we found that both the 2(nd) and 3(rd) dose of CoronaVac vaccination elicited robust IFN-γ-producing NK cell response. Our data provided necessary insights on innate immune responses in the context of three homologous CoronaVac dose vaccination, and supplied immunological basis for the future design of inactivated vaccines against SARS-CoV-2 or other viruses. Frontiers Media S.A. 2023-10-02 /pmc/articles/PMC10577214/ /pubmed/37849746 http://dx.doi.org/10.3389/fimmu.2023.1277831 Text en Copyright © 2023 Cao, Jiang, Liu, Dai, Chang, Ji and Gong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cao, Cheng
Jiang, Junfeng
Liu, Min
Dai, Yaping
Chang, Tianzhi
Ji, Tuo
Gong, Fang
Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
title Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
title_full Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
title_fullStr Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
title_full_unstemmed Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
title_short Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine
title_sort longitudinal evaluation of innate immune responses to three doses of coronavac vaccine
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577214/
https://www.ncbi.nlm.nih.gov/pubmed/37849746
http://dx.doi.org/10.3389/fimmu.2023.1277831
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