Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABA(A) receptors, in a mouse model of Dravet syndrome

Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na channel. Pre-synaptic inhibitory dysfunction is regard...

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Detalles Bibliográficos
Autores principales: Nakakubo, Sachiko, Hiramatsu, Yasuyoshi, Goto, Takeru, Kimura, Syuhei, Narugami, Masashi, Nakajima, Midori, Ueda, Yuki, Shiraishi, Hideaki, Manabe, Atsushi, Sharmin, Dishary, Cook, James M., Egawa, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577232/
https://www.ncbi.nlm.nih.gov/pubmed/37849734
http://dx.doi.org/10.3389/fphar.2023.1273633

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