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Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection

BACKGROUND: Hypercoagulable state in acute ischemic stroke patients with COVID-19, was found to occur in most cases, may affect the severity and clinical outcome of acute ischemic stroke with COVID-19. Ischemic stroke patients with COVID-19 infection have worsen prognosis in mortality regarding hype...

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Autor principal: Amalia, Lisda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577248/
https://www.ncbi.nlm.nih.gov/pubmed/37849564
http://dx.doi.org/10.2147/JBM.S429357
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author Amalia, Lisda
author_facet Amalia, Lisda
author_sort Amalia, Lisda
collection PubMed
description BACKGROUND: Hypercoagulable state in acute ischemic stroke patients with COVID-19, was found to occur in most cases, may affect the severity and clinical outcome of acute ischemic stroke with COVID-19. Ischemic stroke patients with COVID-19 infection have worsen prognosis in mortality regarding hypercoagulable state condition. OBJECTIVE: The study aims to determine the relationship between the hypercoagulable state and the severity of acute ischemic stroke patients with COVID-19. METHODS: This study is a retrospective analytic study using a cross-sectional method in acute ischemic stroke who meet the criteria must have focal clinical symptoms or global dysfunction lasting more than 24 hours, be caused by vascular factors, be confirmed positive for COVID-19, NIHSS (admission and discharge), and have an examination of D-dimer and/or fibrinogen. Chi-Square is used for data processing relationship analysis. RESULTS: A total of 32 patients met the inclusion and exclusion criteria of this study. Elevated D-dimer and/or fibrinogen were found in 28 patients (87.5%), confirming a hypercoagulable state. In this study, the average value of D-dimer was 5.3 mg/mL, and fibrinogen was 479 mg/dL. Based on the admission NIHSS score, it was found that most of the patients had moderate strokes with an average NIHSS score of 12. The chi-square test results showed no relationship between the hypercoagulable state and the severity of acute ischemic stroke as measured by NIHSS admission (p=0.333), but it was closely related to NIHSS exit (p=0.02). The finding supports that 40.62% of acute ischemic stroke patients with COVID-19 confirmed to have a hypercoagulable state had a death discharge status. CONCLUSION: There is no significant relationship between hypercoagulable state and stroke severity on admission, but it closely related to NIHSS on discharge and high mortality in acute ischemic stroke patients with COVID-19.
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spelling pubmed-105772482023-10-17 Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection Amalia, Lisda J Blood Med Original Research BACKGROUND: Hypercoagulable state in acute ischemic stroke patients with COVID-19, was found to occur in most cases, may affect the severity and clinical outcome of acute ischemic stroke with COVID-19. Ischemic stroke patients with COVID-19 infection have worsen prognosis in mortality regarding hypercoagulable state condition. OBJECTIVE: The study aims to determine the relationship between the hypercoagulable state and the severity of acute ischemic stroke patients with COVID-19. METHODS: This study is a retrospective analytic study using a cross-sectional method in acute ischemic stroke who meet the criteria must have focal clinical symptoms or global dysfunction lasting more than 24 hours, be caused by vascular factors, be confirmed positive for COVID-19, NIHSS (admission and discharge), and have an examination of D-dimer and/or fibrinogen. Chi-Square is used for data processing relationship analysis. RESULTS: A total of 32 patients met the inclusion and exclusion criteria of this study. Elevated D-dimer and/or fibrinogen were found in 28 patients (87.5%), confirming a hypercoagulable state. In this study, the average value of D-dimer was 5.3 mg/mL, and fibrinogen was 479 mg/dL. Based on the admission NIHSS score, it was found that most of the patients had moderate strokes with an average NIHSS score of 12. The chi-square test results showed no relationship between the hypercoagulable state and the severity of acute ischemic stroke as measured by NIHSS admission (p=0.333), but it was closely related to NIHSS exit (p=0.02). The finding supports that 40.62% of acute ischemic stroke patients with COVID-19 confirmed to have a hypercoagulable state had a death discharge status. CONCLUSION: There is no significant relationship between hypercoagulable state and stroke severity on admission, but it closely related to NIHSS on discharge and high mortality in acute ischemic stroke patients with COVID-19. Dove 2023-10-11 /pmc/articles/PMC10577248/ /pubmed/37849564 http://dx.doi.org/10.2147/JBM.S429357 Text en © 2023 Amalia. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Amalia, Lisda
Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection
title Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection
title_full Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection
title_fullStr Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection
title_full_unstemmed Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection
title_short Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection
title_sort correlation between hypercoagulable state and severity level of ischemic stroke with covid-19 infection
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577248/
https://www.ncbi.nlm.nih.gov/pubmed/37849564
http://dx.doi.org/10.2147/JBM.S429357
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