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Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective

BACKGROUND: Emergency seizure disorders such as status epilepticus and cluster seizures are unlikely to cease spontaneously while prolonged seizure activity become progressively more resistant to treatment. Early administration of rescue medication in canine epileptic patients, in particular benzodi...

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Autores principales: Kähn, Charlotte, Bhatti, Sofie F. M., Meller, Sebastian, Meyerhoff, Nina, Volk, Holger A., Charalambous, Marios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577269/
https://www.ncbi.nlm.nih.gov/pubmed/37850066
http://dx.doi.org/10.3389/fvets.2023.1278618
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author Kähn, Charlotte
Bhatti, Sofie F. M.
Meller, Sebastian
Meyerhoff, Nina
Volk, Holger A.
Charalambous, Marios
author_facet Kähn, Charlotte
Bhatti, Sofie F. M.
Meller, Sebastian
Meyerhoff, Nina
Volk, Holger A.
Charalambous, Marios
author_sort Kähn, Charlotte
collection PubMed
description BACKGROUND: Emergency seizure disorders such as status epilepticus and cluster seizures are unlikely to cease spontaneously while prolonged seizure activity become progressively more resistant to treatment. Early administration of rescue medication in canine epileptic patients, in particular benzodiazepines, at seizure onset by the owners can be life-saving and brain protecting. Clinical studies in dogs evaluating the use of rescue medication in hospital environment exist, however, the owner perspective has not been assessed to date. HYPOTHESIS OR OBJECTIVES: To evaluate the use of rescue medication in dogs with seizure emergencies by the owner at home. METHOD: Observational study based on online surveys of owners of dogs with emergency seizure disorders. RESULTS: The questionnaire was answered by 1,563 dog owners, of which 761 provided complete and accurate answers suitable for analysis. Of these, 71% administered diazepam, 19% midazolam, 6% levetiracetam, 3% lorazepam, and 4% more than one rescue or other medication. Overall, the success rates based on owners’ perspective for intranasal midazolam and rectal diazepam were 97 and 63%, respectively. Owners reported a compliance level of 95 and 66% for intranasal midazolam and rectal diazepam administration, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: Even though rectal diazepam was the most used rescue medication in this survey population, intranasal midazolam was perceived by the owners as a better option regarding effectiveness, time to seizure cessation and owner compliance.
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spelling pubmed-105772692023-10-17 Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective Kähn, Charlotte Bhatti, Sofie F. M. Meller, Sebastian Meyerhoff, Nina Volk, Holger A. Charalambous, Marios Front Vet Sci Veterinary Science BACKGROUND: Emergency seizure disorders such as status epilepticus and cluster seizures are unlikely to cease spontaneously while prolonged seizure activity become progressively more resistant to treatment. Early administration of rescue medication in canine epileptic patients, in particular benzodiazepines, at seizure onset by the owners can be life-saving and brain protecting. Clinical studies in dogs evaluating the use of rescue medication in hospital environment exist, however, the owner perspective has not been assessed to date. HYPOTHESIS OR OBJECTIVES: To evaluate the use of rescue medication in dogs with seizure emergencies by the owner at home. METHOD: Observational study based on online surveys of owners of dogs with emergency seizure disorders. RESULTS: The questionnaire was answered by 1,563 dog owners, of which 761 provided complete and accurate answers suitable for analysis. Of these, 71% administered diazepam, 19% midazolam, 6% levetiracetam, 3% lorazepam, and 4% more than one rescue or other medication. Overall, the success rates based on owners’ perspective for intranasal midazolam and rectal diazepam were 97 and 63%, respectively. Owners reported a compliance level of 95 and 66% for intranasal midazolam and rectal diazepam administration, respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: Even though rectal diazepam was the most used rescue medication in this survey population, intranasal midazolam was perceived by the owners as a better option regarding effectiveness, time to seizure cessation and owner compliance. Frontiers Media S.A. 2023-10-02 /pmc/articles/PMC10577269/ /pubmed/37850066 http://dx.doi.org/10.3389/fvets.2023.1278618 Text en Copyright © 2023 Kähn, Bhatti, Meller, Meyerhoff, Volk and Charalambous. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kähn, Charlotte
Bhatti, Sofie F. M.
Meller, Sebastian
Meyerhoff, Nina
Volk, Holger A.
Charalambous, Marios
Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
title Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
title_full Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
title_fullStr Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
title_full_unstemmed Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
title_short Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
title_sort out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577269/
https://www.ncbi.nlm.nih.gov/pubmed/37850066
http://dx.doi.org/10.3389/fvets.2023.1278618
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