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Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment

INTRODUCTION: Gastrointestinal (GI) symptoms in kidney transplant are common and debilitating. We aimed to ascertain patients’ preferences for GI symptom management options to help future interventions align with treatment priorities. METHODS: A discrete choice experiment was conducted with kidney t...

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Autores principales: Cooper, Tess E., Dalton, Amy, Kieu, Anh, Gately, Ryan, Bourke, Michael J., Craig, Jonathan C., Khalid, Rabia, Lim, Wai H., Scholes-Robertson, Nicole, Teixeira-Pinto, Armando, Jaure, Allison, Wong, Germaine, Howell, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577360/
https://www.ncbi.nlm.nih.gov/pubmed/37850002
http://dx.doi.org/10.1016/j.ekir.2023.07.034
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author Cooper, Tess E.
Dalton, Amy
Kieu, Anh
Gately, Ryan
Bourke, Michael J.
Craig, Jonathan C.
Khalid, Rabia
Lim, Wai H.
Scholes-Robertson, Nicole
Teixeira-Pinto, Armando
Jaure, Allison
Wong, Germaine
Howell, Martin
author_facet Cooper, Tess E.
Dalton, Amy
Kieu, Anh
Gately, Ryan
Bourke, Michael J.
Craig, Jonathan C.
Khalid, Rabia
Lim, Wai H.
Scholes-Robertson, Nicole
Teixeira-Pinto, Armando
Jaure, Allison
Wong, Germaine
Howell, Martin
author_sort Cooper, Tess E.
collection PubMed
description INTRODUCTION: Gastrointestinal (GI) symptoms in kidney transplant are common and debilitating. We aimed to ascertain patients’ preferences for GI symptom management options to help future interventions align with treatment priorities. METHODS: A discrete choice experiment was conducted with kidney transplant recipients in 3 Australian nephrology units. A multinomial logit model was used to quantify the preferences and trade-offs between 5 characteristics: cost, formulation, symptom burden, dietary changes, and medication quantities. RESULTS: Seventy patients participated (mean age ± SD: 47 ± 15 years, 56% female), 57% had GI symptoms. Patients preferred interventions that will achieve complete resolution of GI symptoms compared to no improvement (odds ratio [95% confidence interval]: 15.3 [1.80, 129.50]), were delivered as a tablet rather than a sachet (1.6 [1.27, 2.08]), retained their current diet compared to eliminating food groups (6.0 [2.19, 16.27]), reduced medication burden (1.4 [1.06, 1.79]), and had lower costs (0.98 [0.96, 1.00]). Participants would be willing to pay AUD$142.20 [$83.90, $200.40] monthly to achieve complete resolution of GI symptoms or AUD$100.90 [$9.60, $192.10] to have moderate improvement in symptoms. CONCLUSIONS: Interventions that are highly effective in relieving all GI symptoms without the need for substantive dietary changes, and in tablet form, are most preferred by kidney transplant recipients.
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spelling pubmed-105773602023-10-17 Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment Cooper, Tess E. Dalton, Amy Kieu, Anh Gately, Ryan Bourke, Michael J. Craig, Jonathan C. Khalid, Rabia Lim, Wai H. Scholes-Robertson, Nicole Teixeira-Pinto, Armando Jaure, Allison Wong, Germaine Howell, Martin Kidney Int Rep Clinical Research INTRODUCTION: Gastrointestinal (GI) symptoms in kidney transplant are common and debilitating. We aimed to ascertain patients’ preferences for GI symptom management options to help future interventions align with treatment priorities. METHODS: A discrete choice experiment was conducted with kidney transplant recipients in 3 Australian nephrology units. A multinomial logit model was used to quantify the preferences and trade-offs between 5 characteristics: cost, formulation, symptom burden, dietary changes, and medication quantities. RESULTS: Seventy patients participated (mean age ± SD: 47 ± 15 years, 56% female), 57% had GI symptoms. Patients preferred interventions that will achieve complete resolution of GI symptoms compared to no improvement (odds ratio [95% confidence interval]: 15.3 [1.80, 129.50]), were delivered as a tablet rather than a sachet (1.6 [1.27, 2.08]), retained their current diet compared to eliminating food groups (6.0 [2.19, 16.27]), reduced medication burden (1.4 [1.06, 1.79]), and had lower costs (0.98 [0.96, 1.00]). Participants would be willing to pay AUD$142.20 [$83.90, $200.40] monthly to achieve complete resolution of GI symptoms or AUD$100.90 [$9.60, $192.10] to have moderate improvement in symptoms. CONCLUSIONS: Interventions that are highly effective in relieving all GI symptoms without the need for substantive dietary changes, and in tablet form, are most preferred by kidney transplant recipients. Elsevier 2023-08-12 /pmc/articles/PMC10577360/ /pubmed/37850002 http://dx.doi.org/10.1016/j.ekir.2023.07.034 Text en © 2023 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Clinical Research
Cooper, Tess E.
Dalton, Amy
Kieu, Anh
Gately, Ryan
Bourke, Michael J.
Craig, Jonathan C.
Khalid, Rabia
Lim, Wai H.
Scholes-Robertson, Nicole
Teixeira-Pinto, Armando
Jaure, Allison
Wong, Germaine
Howell, Martin
Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment
title Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment
title_full Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment
title_fullStr Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment
title_full_unstemmed Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment
title_short Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment
title_sort patient preferences for the management of gastrointestinal symptoms in kidney transplantation: a discrete choice experiment
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577360/
https://www.ncbi.nlm.nih.gov/pubmed/37850002
http://dx.doi.org/10.1016/j.ekir.2023.07.034
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