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The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, defined by a clinical relapse-remitting course. Affecting people worldwide, the origin of IBD is still undefined, arising as a consequence of the interaction between genes, environment, and microbiota....

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Detalles Bibliográficos
Autores principales: Zogorean, Roxana, Wirtz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577428/
https://www.ncbi.nlm.nih.gov/pubmed/37849749
http://dx.doi.org/10.3389/fimmu.2023.1260266
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author Zogorean, Roxana
Wirtz, Stefan
author_facet Zogorean, Roxana
Wirtz, Stefan
author_sort Zogorean, Roxana
collection PubMed
description Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, defined by a clinical relapse-remitting course. Affecting people worldwide, the origin of IBD is still undefined, arising as a consequence of the interaction between genes, environment, and microbiota. Although the root cause is difficult to identify, data clearly indicate that dysbiosis and pathogenic microbial taxa are connected with the establishment and clinical course of IBD. The composition of the microbiota is shaped by plasma cell IgA secretion and binding, while cytokines such as IL10 or IFN-γ are important fine-tuners of the immune response in the gastrointestinal environment. B cells may also influence the course of inflammation by promoting either an anti-inflammatory or a pro-inflammatory milieu. Here, we discuss IgA-producing B regulatory cells as an anti-inflammatory factor in intestinal inflammation. Moreover, we specify the context of IgA and IgG as players that can potentially participate in mucosal inflammation. Finally, we discuss the role of B cells in mouse infection models where IL10, IgA, or IgG contribute to the outcome of the infection.
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spelling pubmed-105774282023-10-17 The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease Zogorean, Roxana Wirtz, Stefan Front Immunol Immunology Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, defined by a clinical relapse-remitting course. Affecting people worldwide, the origin of IBD is still undefined, arising as a consequence of the interaction between genes, environment, and microbiota. Although the root cause is difficult to identify, data clearly indicate that dysbiosis and pathogenic microbial taxa are connected with the establishment and clinical course of IBD. The composition of the microbiota is shaped by plasma cell IgA secretion and binding, while cytokines such as IL10 or IFN-γ are important fine-tuners of the immune response in the gastrointestinal environment. B cells may also influence the course of inflammation by promoting either an anti-inflammatory or a pro-inflammatory milieu. Here, we discuss IgA-producing B regulatory cells as an anti-inflammatory factor in intestinal inflammation. Moreover, we specify the context of IgA and IgG as players that can potentially participate in mucosal inflammation. Finally, we discuss the role of B cells in mouse infection models where IL10, IgA, or IgG contribute to the outcome of the infection. Frontiers Media S.A. 2023-10-02 /pmc/articles/PMC10577428/ /pubmed/37849749 http://dx.doi.org/10.3389/fimmu.2023.1260266 Text en Copyright © 2023 Zogorean and Wirtz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zogorean, Roxana
Wirtz, Stefan
The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
title The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
title_full The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
title_fullStr The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
title_full_unstemmed The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
title_short The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
title_sort yin and yang of b cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577428/
https://www.ncbi.nlm.nih.gov/pubmed/37849749
http://dx.doi.org/10.3389/fimmu.2023.1260266
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