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Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures

Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expres...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao, Zhang, Pengpeng, Cong, Ansheng, Feng, Yanlong, Chi, Hao, Xia, Zhijia, Tang, Hailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577431/
https://www.ncbi.nlm.nih.gov/pubmed/37849766
http://dx.doi.org/10.3389/fimmu.2023.1264325
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author Zhang, Xiao
Zhang, Pengpeng
Cong, Ansheng
Feng, Yanlong
Chi, Hao
Xia, Zhijia
Tang, Hailin
author_facet Zhang, Xiao
Zhang, Pengpeng
Cong, Ansheng
Feng, Yanlong
Chi, Hao
Xia, Zhijia
Tang, Hailin
author_sort Zhang, Xiao
collection PubMed
description Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. Additionally, the influence of the dynamic tumor microenvironment on TET behavior and therapeutic responses is examined. A thorough understanding of these facets elucidates TET pathogenesis, offering avenues for enhancing diagnostic accuracy, refining prognostic assessments, and tailoring targeted therapeutic strategies. Our review underscores the importance of deciphering TETs’ unique molecular signatures to advance personalized treatment paradigms and improve patient outcomes. We also discuss future research directions and anticipated challenges in this intriguing field.
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spelling pubmed-105774312023-10-17 Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures Zhang, Xiao Zhang, Pengpeng Cong, Ansheng Feng, Yanlong Chi, Hao Xia, Zhijia Tang, Hailin Front Immunol Immunology Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. Additionally, the influence of the dynamic tumor microenvironment on TET behavior and therapeutic responses is examined. A thorough understanding of these facets elucidates TET pathogenesis, offering avenues for enhancing diagnostic accuracy, refining prognostic assessments, and tailoring targeted therapeutic strategies. Our review underscores the importance of deciphering TETs’ unique molecular signatures to advance personalized treatment paradigms and improve patient outcomes. We also discuss future research directions and anticipated challenges in this intriguing field. Frontiers Media S.A. 2023-10-02 /pmc/articles/PMC10577431/ /pubmed/37849766 http://dx.doi.org/10.3389/fimmu.2023.1264325 Text en Copyright © 2023 Zhang, Zhang, Cong, Feng, Chi, Xia and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Xiao
Zhang, Pengpeng
Cong, Ansheng
Feng, Yanlong
Chi, Hao
Xia, Zhijia
Tang, Hailin
Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
title Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
title_full Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
title_fullStr Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
title_full_unstemmed Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
title_short Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
title_sort unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577431/
https://www.ncbi.nlm.nih.gov/pubmed/37849766
http://dx.doi.org/10.3389/fimmu.2023.1264325
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