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Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction

BACKGROUND: Anemia is associated with increased rates of heart failure (HF)‐related mortality and hospitalization. No studies have focused on the association between the red blood cell (RBC) count and the prognosis of patients with HF with mildly reduced left ventricular ejection fraction (HFmrEF)....

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Autores principales: Liu, Zhican, Zhu, Yunlong, Zhang, Lingling, Wu, Mingxin, Huang, Haobo, Peng, Ke, Zhao, Wenjiao, Chen, Sihao, Peng, Xin, Li, Na, Zhang, Hui, Zhou, Yuying, Peng, Yiqun, Fan, Jie, Zeng, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577554/
https://www.ncbi.nlm.nih.gov/pubmed/37540056
http://dx.doi.org/10.1002/clc.24108
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author Liu, Zhican
Zhu, Yunlong
Zhang, Lingling
Wu, Mingxin
Huang, Haobo
Peng, Ke
Zhao, Wenjiao
Chen, Sihao
Peng, Xin
Li, Na
Zhang, Hui
Zhou, Yuying
Peng, Yiqun
Fan, Jie
Zeng, Jianping
author_facet Liu, Zhican
Zhu, Yunlong
Zhang, Lingling
Wu, Mingxin
Huang, Haobo
Peng, Ke
Zhao, Wenjiao
Chen, Sihao
Peng, Xin
Li, Na
Zhang, Hui
Zhou, Yuying
Peng, Yiqun
Fan, Jie
Zeng, Jianping
author_sort Liu, Zhican
collection PubMed
description BACKGROUND: Anemia is associated with increased rates of heart failure (HF)‐related mortality and hospitalization. No studies have focused on the association between the red blood cell (RBC) count and the prognosis of patients with HF with mildly reduced left ventricular ejection fraction (HFmrEF). We retrospectively analyzed the effect of the RBC count on outcome events in patients with HFmrEF. METHODS: We investigated the association of the RBC count with outcome events in 1691 patients with HFmrEF (mean age: 68 years; 35% female) in Xiangtan Central Hospital. Using Cox proportional hazards models, the RBC count was assessed as both a continuous and categorical variable. RESULTS: During follow‐up (median: 33 months), cardiovascular death occurred in 168 patients (114 men and 54 women). After adjusting for established risk factors, each 1.0 × 10(12) cell/L increase in the RBC count was associated with a 28% lower risk of cardiovascular death in men and a 43% lower risk in women. Patients with low RBC counts had a 0.5‐fold higher risk of cardiovascular death than those with normal RBC counts. The hazard ratio for men was 1.42 (95% confidence interval [CI]: 1.07–1.89), and the hazard ratio for women was 1.79 (95% CI: 1.20–2.67). The RBC count was not significantly associated with the composite endpoint of cardiovascular death and HF readmission (cardiovascular events) (p > .05). CONCLUSIONS: A decreased RBC count is associated with increased cardiovascular mortality in patients with HFmrEF. Correcting a low RBC count might potentially reduce the risk of cardiovascular death in patients with HFmrEF.
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spelling pubmed-105775542023-10-17 Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction Liu, Zhican Zhu, Yunlong Zhang, Lingling Wu, Mingxin Huang, Haobo Peng, Ke Zhao, Wenjiao Chen, Sihao Peng, Xin Li, Na Zhang, Hui Zhou, Yuying Peng, Yiqun Fan, Jie Zeng, Jianping Clin Cardiol Clinical Trial Result BACKGROUND: Anemia is associated with increased rates of heart failure (HF)‐related mortality and hospitalization. No studies have focused on the association between the red blood cell (RBC) count and the prognosis of patients with HF with mildly reduced left ventricular ejection fraction (HFmrEF). We retrospectively analyzed the effect of the RBC count on outcome events in patients with HFmrEF. METHODS: We investigated the association of the RBC count with outcome events in 1691 patients with HFmrEF (mean age: 68 years; 35% female) in Xiangtan Central Hospital. Using Cox proportional hazards models, the RBC count was assessed as both a continuous and categorical variable. RESULTS: During follow‐up (median: 33 months), cardiovascular death occurred in 168 patients (114 men and 54 women). After adjusting for established risk factors, each 1.0 × 10(12) cell/L increase in the RBC count was associated with a 28% lower risk of cardiovascular death in men and a 43% lower risk in women. Patients with low RBC counts had a 0.5‐fold higher risk of cardiovascular death than those with normal RBC counts. The hazard ratio for men was 1.42 (95% confidence interval [CI]: 1.07–1.89), and the hazard ratio for women was 1.79 (95% CI: 1.20–2.67). The RBC count was not significantly associated with the composite endpoint of cardiovascular death and HF readmission (cardiovascular events) (p > .05). CONCLUSIONS: A decreased RBC count is associated with increased cardiovascular mortality in patients with HFmrEF. Correcting a low RBC count might potentially reduce the risk of cardiovascular death in patients with HFmrEF. John Wiley and Sons Inc. 2023-08-04 /pmc/articles/PMC10577554/ /pubmed/37540056 http://dx.doi.org/10.1002/clc.24108 Text en © 2023 The Authors. Clinical Cardiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Trial Result
Liu, Zhican
Zhu, Yunlong
Zhang, Lingling
Wu, Mingxin
Huang, Haobo
Peng, Ke
Zhao, Wenjiao
Chen, Sihao
Peng, Xin
Li, Na
Zhang, Hui
Zhou, Yuying
Peng, Yiqun
Fan, Jie
Zeng, Jianping
Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
title Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
title_full Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
title_fullStr Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
title_full_unstemmed Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
title_short Red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
title_sort red blood cell count and risk of adverse outcomes in patients with mildly reduced left ventricular ejection fraction
topic Clinical Trial Result
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577554/
https://www.ncbi.nlm.nih.gov/pubmed/37540056
http://dx.doi.org/10.1002/clc.24108
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