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Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
N(6)‐methyladenosine (m(6)A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvement of RNA m(6)A modification in aging and age‐related diseases...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577575/ https://www.ncbi.nlm.nih.gov/pubmed/37641471 http://dx.doi.org/10.1111/acel.13972 |
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author | Wu, Zeming Ren, Jie Liu, Guang‐Hui |
author_facet | Wu, Zeming Ren, Jie Liu, Guang‐Hui |
author_sort | Wu, Zeming |
collection | PubMed |
description | N(6)‐methyladenosine (m(6)A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvement of RNA m(6)A modification in aging and age‐related diseases has gained increasing attention, making it a promising target for understanding the molecular mechanisms underlying aging and developing new therapeutic strategies. This Perspective article will summarize the current advances in aging‐related m(6)A regulation, highlighting the most significant findings and their implications for our understanding of cellular senescence and aging, and the potential for targeting RNA m(6)A regulation as a therapeutic strategy. We will also discuss the limitations and challenges in this field and provide insights into future research directions. By providing a comprehensive overview of the current state of the field, this Perspective article aims to facilitate further advances in our understanding of the molecular mechanisms underlying aging and to identify new therapeutic targets for aging‐related diseases. |
format | Online Article Text |
id | pubmed-10577575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105775752023-10-17 Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions Wu, Zeming Ren, Jie Liu, Guang‐Hui Aging Cell Perspective N(6)‐methyladenosine (m(6)A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvement of RNA m(6)A modification in aging and age‐related diseases has gained increasing attention, making it a promising target for understanding the molecular mechanisms underlying aging and developing new therapeutic strategies. This Perspective article will summarize the current advances in aging‐related m(6)A regulation, highlighting the most significant findings and their implications for our understanding of cellular senescence and aging, and the potential for targeting RNA m(6)A regulation as a therapeutic strategy. We will also discuss the limitations and challenges in this field and provide insights into future research directions. By providing a comprehensive overview of the current state of the field, this Perspective article aims to facilitate further advances in our understanding of the molecular mechanisms underlying aging and to identify new therapeutic targets for aging‐related diseases. John Wiley and Sons Inc. 2023-08-28 /pmc/articles/PMC10577575/ /pubmed/37641471 http://dx.doi.org/10.1111/acel.13972 Text en © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspective Wu, Zeming Ren, Jie Liu, Guang‐Hui Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions |
title | Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions |
title_full | Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions |
title_fullStr | Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions |
title_full_unstemmed | Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions |
title_short | Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions |
title_sort | deciphering rna m(6)a regulation in aging: perspectives on current advances and future directions |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577575/ https://www.ncbi.nlm.nih.gov/pubmed/37641471 http://dx.doi.org/10.1111/acel.13972 |
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