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Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions

N(6)‐methyladenosine (m(6)A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvement of RNA m(6)A modification in aging and age‐related diseases...

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Detalles Bibliográficos
Autores principales: Wu, Zeming, Ren, Jie, Liu, Guang‐Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577575/
https://www.ncbi.nlm.nih.gov/pubmed/37641471
http://dx.doi.org/10.1111/acel.13972
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author Wu, Zeming
Ren, Jie
Liu, Guang‐Hui
author_facet Wu, Zeming
Ren, Jie
Liu, Guang‐Hui
author_sort Wu, Zeming
collection PubMed
description N(6)‐methyladenosine (m(6)A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvement of RNA m(6)A modification in aging and age‐related diseases has gained increasing attention, making it a promising target for understanding the molecular mechanisms underlying aging and developing new therapeutic strategies. This Perspective article will summarize the current advances in aging‐related m(6)A regulation, highlighting the most significant findings and their implications for our understanding of cellular senescence and aging, and the potential for targeting RNA m(6)A regulation as a therapeutic strategy. We will also discuss the limitations and challenges in this field and provide insights into future research directions. By providing a comprehensive overview of the current state of the field, this Perspective article aims to facilitate further advances in our understanding of the molecular mechanisms underlying aging and to identify new therapeutic targets for aging‐related diseases.
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spelling pubmed-105775752023-10-17 Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions Wu, Zeming Ren, Jie Liu, Guang‐Hui Aging Cell Perspective N(6)‐methyladenosine (m(6)A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvement of RNA m(6)A modification in aging and age‐related diseases has gained increasing attention, making it a promising target for understanding the molecular mechanisms underlying aging and developing new therapeutic strategies. This Perspective article will summarize the current advances in aging‐related m(6)A regulation, highlighting the most significant findings and their implications for our understanding of cellular senescence and aging, and the potential for targeting RNA m(6)A regulation as a therapeutic strategy. We will also discuss the limitations and challenges in this field and provide insights into future research directions. By providing a comprehensive overview of the current state of the field, this Perspective article aims to facilitate further advances in our understanding of the molecular mechanisms underlying aging and to identify new therapeutic targets for aging‐related diseases. John Wiley and Sons Inc. 2023-08-28 /pmc/articles/PMC10577575/ /pubmed/37641471 http://dx.doi.org/10.1111/acel.13972 Text en © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Wu, Zeming
Ren, Jie
Liu, Guang‐Hui
Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
title Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
title_full Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
title_fullStr Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
title_full_unstemmed Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
title_short Deciphering RNA m(6)A regulation in aging: Perspectives on current advances and future directions
title_sort deciphering rna m(6)a regulation in aging: perspectives on current advances and future directions
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577575/
https://www.ncbi.nlm.nih.gov/pubmed/37641471
http://dx.doi.org/10.1111/acel.13972
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