In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis

Homologous recombination (HR) is a prominent DNA repair pathway maintaining genome integrity. Mutations in many HR genes lead to cancer predisposition. Paradoxically, the implication of the pivotal HR factor RAD51 on cancer development remains puzzling. Particularly, no RAD51 mouse models are availa...

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Detalles Bibliográficos
Autores principales: Matos‐Rodrigues, Gabriel, Barroca, Vilma, Muhammad, Ali‐Akbar, Dardillac, Elodie, Allouch, Awatef, Koundrioukoff, Stephane, Lewandowski, Daniel, Despras, Emmanuelle, Guirouilh‐Barbat, Josée, Frappart, Lucien, Kannouche, Patricia, Dupaigne, Pauline, Le Cam, Eric, Perfettini, Jean‐Luc, Romeo, Paul‐Henri, Debatisse, Michelle, Jasin, Maria, Livera, Gabriel, Martini, Emmanuelle, Lopez, Bernard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577633/
https://www.ncbi.nlm.nih.gov/pubmed/37661798
http://dx.doi.org/10.15252/embj.2022110844

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