A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis

[Image: see text] Cystic fibrosis (CF) is an autosomal genetic disorder caused by disrupted anion transport in epithelial cells lining tissues in the human airways and digestive system. While cystic fibrosis transmembrane conductance regulator (CFTR) modulator compounds have provided transformative...

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Detalles Bibliográficos
Autores principales: Rab, Andras, Yang, Xun, Tracy, William F., Hong, Jeong S., Joshi, Disha, Manfredi, Candela, Ponnaluri, Sadhana S., Kolykhalov, Alexander A., Qui, Min, Fu, Haian, Du, Yuhong, Davies, Huw M. L., Sorscher, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577695/
https://www.ncbi.nlm.nih.gov/pubmed/37849531
http://dx.doi.org/10.1021/acsmedchemlett.3c00155

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