Cargando…

The mitochondrial fusion-associated protein MFN2 can be used as a novel prognostic molecule for clear cell renal cell carcinoma

BACKGROUND: Mitofusin 2 (MFN2) plays an important role in many tumors, but how its role in renal clear cell carcinoma needs further research. METHODS: In this study, we analyzed the expression of MFN2 in renal clear cell carcinoma tissues and normal kidney tissues through the Cancer Genome Atlas (TC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Bin, Han, Dali, Yang, LiMing, He, Yang, Yang, Shujun, Wang, Hongbo, Zhang, Xingxing, Du, Yuelin, Xiong, Wei, Ha, Hualan, Shang, Panfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577979/ https://www.ncbi.nlm.nih.gov/pubmed/37845657 http://dx.doi.org/10.1186/s12885-023-11419-8

Ejemplares similares

Mfn1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
por: Cao, Yu-Lu, et al.
Publicado: (2017)

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
por: Chen, Hsiuchen, et al.
Publicado: (2003)

FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion
por: Li, Shuaifeng, et al.
Publicado: (2022)

Comprehensive analysis of fatty acid metabolism-related gene signatures for predicting prognosis in patients with prostate cancer
por: Wang, Hongbo, et al.
Publicado: (2023)

MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria‐dependent dephosphorylation of EGFR
por: Luo, Li, et al.
Publicado: (2023)

Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
por: Chen, Lei, et al.
Publicado: (2021)

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth
por: Li, Meng, et al.
Publicado: (2020)

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
por: Detmer, Scott A., et al.
Publicado: (2007)

STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
por: Kim, Hyunmi, et al.
Publicado: (2022)

STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion
por: Li, Changfeng, et al.
Publicado: (2021)

Trophoblast Stem-Cell-Derived Exosomes Alleviate Cardiotoxicity of Doxorubicin via Improving Mfn2-Mediated Mitochondrial Fusion
por: Duan, Junfeng, et al.
Publicado: (2023)

MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
por: Miao, Junru, et al.
Publicado: (2021)

Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1
por: Jung Kim, Min
Publicado: (2018)

Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function
por: Ma, Zhuang, et al.
Publicado: (2023)

Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer
por: Liang, Xiaohua, et al.
Publicado: (2021)

Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis
por: Zhao, Na, et al.
Publicado: (2015)

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity
por: Zhang, Shun, et al.
Publicado: (2023)

MFN2 mutations cause compensatory mitochondrial DNA proliferation
por: Sitarz, Kamil S., et al.
Publicado: (2012)

The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology
por: Zaman, Mashiat, et al.
Publicado: (2022)

Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch
por: Ding, Mingge, et al.
Publicado: (2022)

The Mitochondrial Fusion-Related Proteins Mfn2 and OPA1 are Transcriptionally Induced during Differentiation of Bone Marrow Progenitors to Immature Dendritic Cells
por: Ryu, Seung-Wook, et al.
Publicado: (2015)

MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation
por: Chen, Wei, et al.
Publicado: (2020)

Cordycepin Decreases Ischemia/Reperfusion Injury in Diabetic Hearts via Upregulating AMPK/Mfn2-dependent Mitochondrial Fusion
por: Yu, Houyou, et al.
Publicado: (2021)

The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
por: Huo, Yinbo, et al.
Publicado: (2022)

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion
por: Georgiadou, Eleni, et al.
Publicado: (2022)

Mitochondrial Dynamics Mediated by DRP1 and MFN2 Contributes to Cisplatin Chemoresistance in Human Ovarian Cancer SKOV3 cells
por: Zou, Guang-Ping, et al.
Publicado: (2021)

MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival
por: Park, Y-Y, et al.
Publicado: (2014)

HIV-1 Vpr Triggers Mitochondrial Destruction by Impairing Mfn2-Mediated ER-Mitochondria Interaction
por: Huang, Chih-Yang, et al.
Publicado: (2012)

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
por: Hall, A R, et al.
Publicado: (2016)

Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
por: Sloat, S. R., et al.
Publicado: (2019)

Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy
por: Hu, Lang, et al.
Publicado: (2019)

Mitochondrial fusion protein MFN2 interacts with the mitostatin-related protein MNS1 required for mouse sperm flagellar structure and function
por: Vadnais, Melissa L, et al.
Publicado: (2014)

Mfn2 Overexpression Attenuates Cardio-Cerebrovascular Ischemia–Reperfusion Injury Through Mitochondrial Fusion and Activation of the AMPK/Sirt3 Signaling
por: Liu, Min, et al.
Publicado: (2020)

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
por: Karbowski, Mariusz, et al.
Publicado: (2002)

Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
por: Hall, A. R., et al.
Publicado: (2021)

MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice
por: Wang, Tianren, et al.
Publicado: (2022)

Retraction: Mfn2 overexpression attenuates Cardio-Cerebrovascular Ischemia–Reperfusion injury through mitochondrial fusion and activation of the AMPK/Sirt3 signaling
Publicado: (2022)

Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia
por: Liu, Wanying, et al.
Publicado: (2022)

Clinical application and efficacy analysis of partial cystectomy combined with intravesical chemotherapy in muscle-invasive bladder cancer
por: Zhang, Bin, et al.
Publicado: (2023)

Mitochondrial Features and Expressions of MFN2 and DRP1 during Spermiogenesis in Phascolosoma esculenta
por: Gao, Xinming, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bfj1sak6afen6gtitbt7t3bqlp