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Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577991/ https://www.ncbi.nlm.nih.gov/pubmed/37845726 http://dx.doi.org/10.1186/s12964-023-01323-w |
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author | Jiang, Shan Su, Hua |
author_facet | Jiang, Shan Su, Hua |
author_sort | Jiang, Shan |
collection | PubMed |
description | Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its pathogenesis. Nonetheless, the cellular crosstalk of podocytes and endothelial cells in DKD is better understood than that of mesangial cells (MCs) and renal tubular epithelial cells (TECs). As the significance of MCs and TECs in DKD pathophysiology has recently become more apparent, we reviewed the existing literature on the cellular crosstalk of MCs and TECs in the context of DKD to acquire a comprehensive understanding of their cellular communication. Insights into the complicated mechanisms underlying the pathophysiology of DKD would improve its early detection, care, and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01323-w. |
format | Online Article Text |
id | pubmed-10577991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105779912023-10-17 Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease Jiang, Shan Su, Hua Cell Commun Signal Review Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its pathogenesis. Nonetheless, the cellular crosstalk of podocytes and endothelial cells in DKD is better understood than that of mesangial cells (MCs) and renal tubular epithelial cells (TECs). As the significance of MCs and TECs in DKD pathophysiology has recently become more apparent, we reviewed the existing literature on the cellular crosstalk of MCs and TECs in the context of DKD to acquire a comprehensive understanding of their cellular communication. Insights into the complicated mechanisms underlying the pathophysiology of DKD would improve its early detection, care, and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01323-w. BioMed Central 2023-10-16 /pmc/articles/PMC10577991/ /pubmed/37845726 http://dx.doi.org/10.1186/s12964-023-01323-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Jiang, Shan Su, Hua Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
title | Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
title_full | Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
title_fullStr | Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
title_full_unstemmed | Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
title_short | Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
title_sort | cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577991/ https://www.ncbi.nlm.nih.gov/pubmed/37845726 http://dx.doi.org/10.1186/s12964-023-01323-w |
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