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Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease

Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its p...

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Autores principales: Jiang, Shan, Su, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577991/
https://www.ncbi.nlm.nih.gov/pubmed/37845726
http://dx.doi.org/10.1186/s12964-023-01323-w
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author Jiang, Shan
Su, Hua
author_facet Jiang, Shan
Su, Hua
author_sort Jiang, Shan
collection PubMed
description Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its pathogenesis. Nonetheless, the cellular crosstalk of podocytes and endothelial cells in DKD is better understood than that of mesangial cells (MCs) and renal tubular epithelial cells (TECs). As the significance of MCs and TECs in DKD pathophysiology has recently become more apparent, we reviewed the existing literature on the cellular crosstalk of MCs and TECs in the context of DKD to acquire a comprehensive understanding of their cellular communication. Insights into the complicated mechanisms underlying the pathophysiology of DKD would improve its early detection, care, and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01323-w.
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spelling pubmed-105779912023-10-17 Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease Jiang, Shan Su, Hua Cell Commun Signal Review Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular crosstalk involved in DKD is a promising avenue for gaining a better understanding of its pathogenesis. Nonetheless, the cellular crosstalk of podocytes and endothelial cells in DKD is better understood than that of mesangial cells (MCs) and renal tubular epithelial cells (TECs). As the significance of MCs and TECs in DKD pathophysiology has recently become more apparent, we reviewed the existing literature on the cellular crosstalk of MCs and TECs in the context of DKD to acquire a comprehensive understanding of their cellular communication. Insights into the complicated mechanisms underlying the pathophysiology of DKD would improve its early detection, care, and prognosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01323-w. BioMed Central 2023-10-16 /pmc/articles/PMC10577991/ /pubmed/37845726 http://dx.doi.org/10.1186/s12964-023-01323-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Jiang, Shan
Su, Hua
Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
title Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
title_full Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
title_fullStr Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
title_full_unstemmed Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
title_short Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
title_sort cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577991/
https://www.ncbi.nlm.nih.gov/pubmed/37845726
http://dx.doi.org/10.1186/s12964-023-01323-w
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