Cargando…
De novo design of monomeric helical bundles for pH‐controlled membrane lysis
Targeted intracellular delivery via receptor‐mediated endocytosis requires the delivered cargo to escape the endosome to prevent lysosomal degradation. This can in principle be achieved by membrane lysis tightly restricted to endosomal membranes upon internalization to avoid general membrane inserti...
Autores principales: | Goldbach, Nicolas, Benna, Issa, Wicky, Basile I. M., Croft, Jacob T., Carter, Lauren, Bera, Asim K., Nguyen, Hannah, Kang, Alex, Sankaran, Banumathi, Yang, Erin C., Lee, Kelly K., Baker, David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578055/ https://www.ncbi.nlm.nih.gov/pubmed/37632837 http://dx.doi.org/10.1002/pro.4769 |
Ejemplares similares
-
De novo design of protein homodimers containing tunable symmetric protein pockets
por: Hicks, Derrick R., et al.
Publicado: (2022) -
Helices and vector bundles
por: Rudakov, A N
Publicado: (1990) -
Segmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation
por: Merljak, Estera, et al.
Publicado: (2023) -
An enumerative algorithm for de novo design of proteins with diverse pocket structures
por: Basanta, Benjamin, et al.
Publicado: (2020) -
Hallucination of closed repeat proteins containing central pockets
por: An, Linna, et al.
Publicado: (2023)