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Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity

Nanotechnology holds significance in all fields of research, and the formation and surface alterations of nanomaterials are particularly important in this discipline. Nanoformulations synthesized with bioactive plant components play a crucial role in the improvement of several therapeutics and diagn...

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Autores principales: Parmar, Nilam, Mansuri, Abdulkhalik, Trivedi, Krupali, Ansari, Khairah, Kumar, Priyesh, Azim Bagban, Mohammed, Jhala, Devendrasinh, Patel, Alpesh, Chettiar, Shiva Shankaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578130/
https://www.ncbi.nlm.nih.gov/pubmed/37850115
http://dx.doi.org/10.5114/bta.2023.130730
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author Parmar, Nilam
Mansuri, Abdulkhalik
Trivedi, Krupali
Ansari, Khairah
Kumar, Priyesh
Azim Bagban, Mohammed
Jhala, Devendrasinh
Patel, Alpesh
Chettiar, Shiva Shankaran
author_facet Parmar, Nilam
Mansuri, Abdulkhalik
Trivedi, Krupali
Ansari, Khairah
Kumar, Priyesh
Azim Bagban, Mohammed
Jhala, Devendrasinh
Patel, Alpesh
Chettiar, Shiva Shankaran
author_sort Parmar, Nilam
collection PubMed
description Nanotechnology holds significance in all fields of research, and the formation and surface alterations of nanomaterials are particularly important in this discipline. Nanoformulations synthesized with bioactive plant components play a crucial role in the improvement of several therapeutics and diagnostics. In the present study, we reported the synthesis of a curcumin nanoformulation (CN) by using curcumin and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). The synthesized CN was characterized using dynamic light scattering, UV-Visible spectrophotometry, Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, and X-ray diffraction. Furthermore, it was evaluated for solubility, drug loading, encapsulation efficiency, stability, in vitro release, and anticancer potentials. The role of TPGS in the synthesis of CN was validated. The synthesized CN exhibited a size of 6.2 ± 1.9 nm, needle-shaped morphology, a polydispersity index of 0.164, and zeta potential of − 10.1 ± 3.21 mV, as determined by characterization techniques. Its water solubility was 2.5 × 10(4) times higher than that of pure curcumin. The encapsulation efficiency and curcumin loading efficiency of the synthesized CN were found to be 80 and 10%, respectively, with storage stability exceeding 30 days. Moreover, the synthesized CN demonstrated significant in vitro anticancer activity against the colorectal cancer cell line HCT-116, with an IC50 value of 12.74 ± 0.54 μM at 24 h.
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spelling pubmed-105781302023-10-17 Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity Parmar, Nilam Mansuri, Abdulkhalik Trivedi, Krupali Ansari, Khairah Kumar, Priyesh Azim Bagban, Mohammed Jhala, Devendrasinh Patel, Alpesh Chettiar, Shiva Shankaran BioTechnologia (Pozn) Research Papers Nanotechnology holds significance in all fields of research, and the formation and surface alterations of nanomaterials are particularly important in this discipline. Nanoformulations synthesized with bioactive plant components play a crucial role in the improvement of several therapeutics and diagnostics. In the present study, we reported the synthesis of a curcumin nanoformulation (CN) by using curcumin and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). The synthesized CN was characterized using dynamic light scattering, UV-Visible spectrophotometry, Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy, and X-ray diffraction. Furthermore, it was evaluated for solubility, drug loading, encapsulation efficiency, stability, in vitro release, and anticancer potentials. The role of TPGS in the synthesis of CN was validated. The synthesized CN exhibited a size of 6.2 ± 1.9 nm, needle-shaped morphology, a polydispersity index of 0.164, and zeta potential of − 10.1 ± 3.21 mV, as determined by characterization techniques. Its water solubility was 2.5 × 10(4) times higher than that of pure curcumin. The encapsulation efficiency and curcumin loading efficiency of the synthesized CN were found to be 80 and 10%, respectively, with storage stability exceeding 30 days. Moreover, the synthesized CN demonstrated significant in vitro anticancer activity against the colorectal cancer cell line HCT-116, with an IC50 value of 12.74 ± 0.54 μM at 24 h. Termedia Publishing House 2023-09-25 /pmc/articles/PMC10578130/ /pubmed/37850115 http://dx.doi.org/10.5114/bta.2023.130730 Text en © 2023 Institute of Bioorganic Chemistry, Polish Academy of Sciences https://creativecommons.org/licenses/by-nc-nd/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND), allowing third parties to download and share its works but not commercially purposes or to create derivative works.
spellingShingle Research Papers
Parmar, Nilam
Mansuri, Abdulkhalik
Trivedi, Krupali
Ansari, Khairah
Kumar, Priyesh
Azim Bagban, Mohammed
Jhala, Devendrasinh
Patel, Alpesh
Chettiar, Shiva Shankaran
Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
title Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
title_full Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
title_fullStr Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
title_full_unstemmed Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
title_short Formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
title_sort formation, characterization, and analysis of curcumin nanoformulation for evaluating its in vitro cytotoxicity
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578130/
https://www.ncbi.nlm.nih.gov/pubmed/37850115
http://dx.doi.org/10.5114/bta.2023.130730
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