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Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients
BACKGROUND: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients. PATIENTS AND METHODS: One-hundred and fourteen patient...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578180/ https://www.ncbi.nlm.nih.gov/pubmed/37849526 http://dx.doi.org/10.2147/NDT.S413101 |
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author | Bramness, Jørgen G Pandey, Susmita Moe, Jenny Skumsnes Toft, Helge Lien, Lars Walby, Fredrik A Myhre, Martin Øverlien Bolstad, Ingeborg |
author_facet | Bramness, Jørgen G Pandey, Susmita Moe, Jenny Skumsnes Toft, Helge Lien, Lars Walby, Fredrik A Myhre, Martin Øverlien Bolstad, Ingeborg |
author_sort | Bramness, Jørgen G |
collection | PubMed |
description | BACKGROUND: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients. PATIENTS AND METHODS: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) along with several other background variables and clinical characteristics. Serum blood samples were drawn for analysis of cytokines. RESULTS: Thirty-one patients (27%) reported at least one SA. These patients had more symptoms of current affective disorders and more severe dependence. In bivariate analysis only IL-6 and IL-10 appeared to be associated with lifetime SA but without reaching statistical significance. In multivariate linear regression, adjusting for sex, nicotine use, somatic illness, and the use of anti-inflammatory drugs, IL-6 was associated to SA (p = 0.033). CONCLUSION: The cytokine IL-6 has repeatedly been found to be associated with suicidality. The present study concurs with this role of IL-6 in a naturalistic observational study of AUD patients. |
format | Online Article Text |
id | pubmed-10578180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-105781802023-10-17 Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients Bramness, Jørgen G Pandey, Susmita Moe, Jenny Skumsnes Toft, Helge Lien, Lars Walby, Fredrik A Myhre, Martin Øverlien Bolstad, Ingeborg Neuropsychiatr Dis Treat Original Research BACKGROUND: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients. PATIENTS AND METHODS: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) along with several other background variables and clinical characteristics. Serum blood samples were drawn for analysis of cytokines. RESULTS: Thirty-one patients (27%) reported at least one SA. These patients had more symptoms of current affective disorders and more severe dependence. In bivariate analysis only IL-6 and IL-10 appeared to be associated with lifetime SA but without reaching statistical significance. In multivariate linear regression, adjusting for sex, nicotine use, somatic illness, and the use of anti-inflammatory drugs, IL-6 was associated to SA (p = 0.033). CONCLUSION: The cytokine IL-6 has repeatedly been found to be associated with suicidality. The present study concurs with this role of IL-6 in a naturalistic observational study of AUD patients. Dove 2023-10-12 /pmc/articles/PMC10578180/ /pubmed/37849526 http://dx.doi.org/10.2147/NDT.S413101 Text en © 2023 Bramness et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Bramness, Jørgen G Pandey, Susmita Moe, Jenny Skumsnes Toft, Helge Lien, Lars Walby, Fredrik A Myhre, Martin Øverlien Bolstad, Ingeborg Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients |
title | Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients |
title_full | Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients |
title_fullStr | Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients |
title_full_unstemmed | Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients |
title_short | Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients |
title_sort | levels of il-6 are associated with lifetime attempted suicide in alcohol use disorder patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578180/ https://www.ncbi.nlm.nih.gov/pubmed/37849526 http://dx.doi.org/10.2147/NDT.S413101 |
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