Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL

Asparaginase is an important agent for the treatment of acute lymphoblastic leukaemia (ALL), but it is occasionally associated with severe adverse events. Thus, for safer and more efficacious therapy, a clinical biomarker predicting asparaginase sensitivity is highly anticipated. Asparaginase deplet...

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Detalles Bibliográficos
Autores principales: Watanabe, Atsushi, Miyake, Kunio, Yamada, Yuriko, Sunamura, Ei-Ichiro, Yotani, Takuya, Kagami, Keiko, Kasai, Shin, Tamai, Minori, Harama, Daisuke, Akahane, Koshi, Goi, Kumiko, Sakaguchi, Kimiyoshi, Goto, Hiroaki, Kitahara, Shinichiro, Inukai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578186/
https://www.ncbi.nlm.nih.gov/pubmed/37839090
http://dx.doi.org/10.1080/15592294.2023.2268814

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