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Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer’s Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer’s Disease

BACKGROUND: Bleomycin hydrolase (BLMH), a homocysteine (Hcy)-thiolactone detoxifying enzyme, is attenuated in Alzheimer’s disease (AD) brains. Blmh loss causes astrogliosis in mice while the loss of histone demethylase Phf8, which controls mTOR signaling, causes neuropathy in mice and humans. OBJECT...

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Detalles Bibliográficos
Autores principales:	Witucki, Łukasz, Borowczyk, Kamila, Suszyńska-Zajczyk, Joanna, Warzych, Ewelina, Pawlak, Piotr, Jakubowski, Hieronim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578231/ https://www.ncbi.nlm.nih.gov/pubmed/37718819 http://dx.doi.org/10.3233/JAD-230578

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