Cargando…

Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans

BACKGROUND: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer’s disease. OBJECTIVE: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Marcolini, Sofia, Rojczyk, Philine, Seitz-Holland, Johanna, Koerte, Inga K., Alosco, Michael L., Bouix, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578246/
https://www.ncbi.nlm.nih.gov/pubmed/37694363
http://dx.doi.org/10.3233/JAD-221304
_version_ 1785121480278802432
author Marcolini, Sofia
Rojczyk, Philine
Seitz-Holland, Johanna
Koerte, Inga K.
Alosco, Michael L.
Bouix, Sylvain
author_facet Marcolini, Sofia
Rojczyk, Philine
Seitz-Holland, Johanna
Koerte, Inga K.
Alosco, Michael L.
Bouix, Sylvain
author_sort Marcolini, Sofia
collection PubMed
description BACKGROUND: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer’s disease. OBJECTIVE: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and neuroimaging measures in Vietnam war Veterans. METHODS: Data were acquired at baseline and after about one-year from male Veterans categorized into: PTSD, TBI, PTSD+TBI, and Veteran controls without PTSD or TBI. We applied manual tractography to examine white matter microstructure of three fiber tracts: uncinate fasciculus (N = 91), cingulum (N = 87), and inferior longitudinal fasciculus (N = 95). ANCOVAs were used to compare Veterans’ baseline behavioral and cognitive functioning (N = 285), white matter microstructure, amyloid-β (N = 230), and tau PET (N = 120). Additional ANCOVAs examined scores’ differences from baseline to follow-up. RESULTS: Veterans with PTSD and PTSD+TBI, but not Veterans with TBI only, exhibited poorer behavioral and cognitive functioning at baseline than controls. The groups did not differ in baseline white matter, amyloid-β, or tau, nor in behavioral and cognitive functioning, and tau accumulation change. Progression of white matter abnormalities of the uncinate fasciculus in Veterans with PTSD compared to controls was observed; analyses in TBI and PTSD+TBI were not run due to insufficient sample size. CONCLUSIONS: PTSD and PTSD+TBI negatively affect behavioral and cognitive functioning, while TBI does not contribute independently. Whether progressive decline in uncinate fasciculus microstructure in Veterans with PTSD might account for cognitive decline should be further studied. Findings did not support an association between PTSD, TBI, and Alzheimer’s disease pathology based on amyloid and tau PET.
format Online
Article
Text
id pubmed-10578246
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-105782462023-10-17 Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans Marcolini, Sofia Rojczyk, Philine Seitz-Holland, Johanna Koerte, Inga K. Alosco, Michael L. Bouix, Sylvain J Alzheimers Dis Research Article BACKGROUND: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer’s disease. OBJECTIVE: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and neuroimaging measures in Vietnam war Veterans. METHODS: Data were acquired at baseline and after about one-year from male Veterans categorized into: PTSD, TBI, PTSD+TBI, and Veteran controls without PTSD or TBI. We applied manual tractography to examine white matter microstructure of three fiber tracts: uncinate fasciculus (N = 91), cingulum (N = 87), and inferior longitudinal fasciculus (N = 95). ANCOVAs were used to compare Veterans’ baseline behavioral and cognitive functioning (N = 285), white matter microstructure, amyloid-β (N = 230), and tau PET (N = 120). Additional ANCOVAs examined scores’ differences from baseline to follow-up. RESULTS: Veterans with PTSD and PTSD+TBI, but not Veterans with TBI only, exhibited poorer behavioral and cognitive functioning at baseline than controls. The groups did not differ in baseline white matter, amyloid-β, or tau, nor in behavioral and cognitive functioning, and tau accumulation change. Progression of white matter abnormalities of the uncinate fasciculus in Veterans with PTSD compared to controls was observed; analyses in TBI and PTSD+TBI were not run due to insufficient sample size. CONCLUSIONS: PTSD and PTSD+TBI negatively affect behavioral and cognitive functioning, while TBI does not contribute independently. Whether progressive decline in uncinate fasciculus microstructure in Veterans with PTSD might account for cognitive decline should be further studied. Findings did not support an association between PTSD, TBI, and Alzheimer’s disease pathology based on amyloid and tau PET. IOS Press 2023-10-10 /pmc/articles/PMC10578246/ /pubmed/37694363 http://dx.doi.org/10.3233/JAD-221304 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Marcolini, Sofia
Rojczyk, Philine
Seitz-Holland, Johanna
Koerte, Inga K.
Alosco, Michael L.
Bouix, Sylvain
Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans
title Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans
title_full Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans
title_fullStr Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans
title_full_unstemmed Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans
title_short Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans
title_sort posttraumatic stress and traumatic brain injury: cognition, behavior, and neuroimaging markers in vietnam veterans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578246/
https://www.ncbi.nlm.nih.gov/pubmed/37694363
http://dx.doi.org/10.3233/JAD-221304
work_keys_str_mv AT marcolinisofia posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans
AT rojczykphiline posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans
AT seitzhollandjohanna posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans
AT koerteingak posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans
AT aloscomichaell posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans
AT bouixsylvain posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans
AT posttraumaticstressandtraumaticbraininjurycognitionbehaviorandneuroimagingmarkersinvietnamveterans