Efficacy of Adjunctive Therapy with Zonisamide Versus Increased Dose of Levodopa for Motor Symptoms in Patients with Dementia with Lewy Bodies: The Randomized, Controlled, Non-Inferiority DUEL Study

BACKGROUND: In patients with dementia with Lewy bodies (DLB), it is unknown whether adjunct zonisamide is as effective and safe as increasing levodopa dose when levodopa has inadequate efficacy on parkinsonism. OBJECTIVE: To compare adjunct zonisamide 25 mg/day versus an increased levodopa dose (inc...

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Detalles Bibliográficos
Autores principales: Ikeda, Manabu, Mori, Etsuro, Orimo, Satoshi, Yamada, Tomomi, Konishi, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578290/
https://www.ncbi.nlm.nih.gov/pubmed/37483001
http://dx.doi.org/10.3233/JAD-230335

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