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Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A

[Image: see text] A marine cyanobacterial cyclic depsipeptide, coibamide A (CbA), inhibits the mammalian protein secretory pathway by blocking the Sec61 translocon, which is an emerging drug target for cancer and other chronic diseases. In our previous structure–activity relationship study of CbA, t...

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Detalles Bibliográficos
Autores principales:	Suzuki, Rikito, Mattos, Daphne R., Kitamura, Takashi, Tsujioka, Rina, Kobayashi, Kazuya, Inuki, Shinsuke, Ohno, Hiroaki, Ishmael, Jane E., McPhail, Kerry L., Oishi, Shinya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578308/ https://www.ncbi.nlm.nih.gov/pubmed/37849553 http://dx.doi.org/10.1021/acsmedchemlett.3c00232

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