Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole

[Image: see text] The neuroprotective transcription factor Nurr1 was recently found to bind the dopamine metabolite 5,6-dihydroxyindole (DHI) providing access to Nurr1 ligand design from a natural template. We screened a custom set of 14 k extended DHI analogues in silico for optimized descendants t...

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Detalles Bibliográficos
Autores principales: Sai, Minh, Vietor, Jan, Kornmayer, Moritz, Egner, Markus, López-García, Úrsula, Höfner, Georg, Pabel, Jörg, Marschner, Julian A., Wein, Thomas, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578347/
https://www.ncbi.nlm.nih.gov/pubmed/37751901
http://dx.doi.org/10.1021/acs.jmedchem.3c00852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578347/
https://www.ncbi.nlm.nih.gov/pubmed/37751901
http://dx.doi.org/10.1021/acs.jmedchem.3c00852

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