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Free Energy Simulations of Receptor-Binding Domain Opening of the SARS-CoV-2 Spike Indicate a Barrierless Transition with Slow Conformational Motions
[Image: see text] Infection by sarbecoviruses begins with the attachment of the homotrimeric viral “spike” protein to the angiotensin-converting enzyme 2 receptor on the surface of mammalian cells. This requires one or more receptor-binding domains (RBDs) to be in the open (up) position. Here, we pr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578350/ https://www.ncbi.nlm.nih.gov/pubmed/37756691 http://dx.doi.org/10.1021/acs.jpcb.3c05236 |