Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

[Image: see text] The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor groove binders. We report the synthesis, antiprotozoal screening, and SAR studies of three series of analogues of the known antiprotozoal kDNA binder 2-((4-(4-((4,5-dihydro-1H-imidazol-3-ium-2...

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Detalles Bibliográficos
Autores principales: Nué-Martinez, J. Jonathan, Cisneros, David, Moreno-Blázquez, María del Valle, Fonseca-Berzal, Cristina, Manzano, José Ignacio, Kraeutler, Damien, Ungogo, Marzuq A., Aloraini, Maha A., Elati, Hamza A. A., Ibáñez-Escribano, Alexandra, Lagartera, Laura, Herraiz, Tomás, Gamarro, Francisco, de Koning, Harry P., Gómez-Barrio, Alicia, Dardonville, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578353/
https://www.ncbi.nlm.nih.gov/pubmed/37729094
http://dx.doi.org/10.1021/acs.jmedchem.3c00697

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