Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism

The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-associated degradation (ERAD) complex, the primary molecular mac...

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Detalles Bibliográficos
Autores principales: Abdon, Benedict, Liang, Yusheng, da Luz Scheffer, Débora, Torres, Mauricio, Shrestha, Neha, Reinert, Rachel B., Lu, You, Pederson, Brent, Bugarin-Lapuz, Amara, Kersten, Sander, Qi, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578429/
https://www.ncbi.nlm.nih.gov/pubmed/37535424
http://dx.doi.org/10.1172/jci.insight.170387

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