Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain

Benzodiazepine (BZ) drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by potentiating γ2 subunit containing GABA type A receptors (GABA(A)Rs). BZ clinical use is hampered by tolerance and withdrawal symptoms including heightened seizure susceptibility, panic, and sleep disturbances. He...

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Detalles Bibliográficos
Autores principales: Lorenz-Guertin, Joshua M., Povysheva, Nadya, Chapman, Caitlyn A., MacDonald, Matthew L., Fazzari, Marco, Nigam, Aparna, Nuwer, Jessica L., Das, Sabyasachi, Brady, Megan L., Vajn, Katarina, Bambino, Matthew J., Weintraub, Susan T., Johnson, Jon W., Jacob, Tija C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578451/
https://www.ncbi.nlm.nih.gov/pubmed/37536384
http://dx.doi.org/10.1016/j.nbd.2023.106248

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