Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review

Kaposi sarcoma (KS) is a low-grade mesenchymal angioproliferative disorder that requires infection with human herpes virus 8 (HHV-8) for it to develop. It is commonly seen in HIV-positive patients and rarely in immunosuppressed HIV-negative patients. Rituximab is a monoclonal anti-CD20 chimeric muri...

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Autores principales: Oprita, Alexandru, Cotan, Horia, Celmare, Dana, Emilescu, Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578454/
https://www.ncbi.nlm.nih.gov/pubmed/37849608
http://dx.doi.org/10.7759/cureus.45365
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author Oprita, Alexandru
Cotan, Horia
Celmare, Dana
Emilescu, Radu
author_facet Oprita, Alexandru
Cotan, Horia
Celmare, Dana
Emilescu, Radu
author_sort Oprita, Alexandru
collection PubMed
description Kaposi sarcoma (KS) is a low-grade mesenchymal angioproliferative disorder that requires infection with human herpes virus 8 (HHV-8) for it to develop. It is commonly seen in HIV-positive patients and rarely in immunosuppressed HIV-negative patients. Rituximab is a monoclonal anti-CD20 chimeric murine/human immunoglobulin G antibody used to treat B cell lymphoproliferative diseases as well as a variety of autoimmune disorders. Several cases of iatrogenic Kaposi sarcoma (iKS) have been described after rituximab treatment. The purpose of this narrative review is to identify the presence of common clinical characteristics among rituximab-induced KS patients that could facilitate better management of this rare condition.
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spelling pubmed-105784542023-10-17 Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review Oprita, Alexandru Cotan, Horia Celmare, Dana Emilescu, Radu Cureus Dermatology Kaposi sarcoma (KS) is a low-grade mesenchymal angioproliferative disorder that requires infection with human herpes virus 8 (HHV-8) for it to develop. It is commonly seen in HIV-positive patients and rarely in immunosuppressed HIV-negative patients. Rituximab is a monoclonal anti-CD20 chimeric murine/human immunoglobulin G antibody used to treat B cell lymphoproliferative diseases as well as a variety of autoimmune disorders. Several cases of iatrogenic Kaposi sarcoma (iKS) have been described after rituximab treatment. The purpose of this narrative review is to identify the presence of common clinical characteristics among rituximab-induced KS patients that could facilitate better management of this rare condition. Cureus 2023-09-16 /pmc/articles/PMC10578454/ /pubmed/37849608 http://dx.doi.org/10.7759/cureus.45365 Text en Copyright © 2023, Oprita et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Oprita, Alexandru
Cotan, Horia
Celmare, Dana
Emilescu, Radu
Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review
title Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review
title_full Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review
title_fullStr Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review
title_full_unstemmed Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review
title_short Rituximab-Induced Kaposi Sarcoma in HIV-Negative Patients: A Narrative Review
title_sort rituximab-induced kaposi sarcoma in hiv-negative patients: a narrative review
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578454/
https://www.ncbi.nlm.nih.gov/pubmed/37849608
http://dx.doi.org/10.7759/cureus.45365
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