Localization of unlabeled bepirovirsen antisense oligonucleotide in murine tissues using in situ hybridization and CARS imaging

Current methods for detecting unlabeled antisense oligonucleotide (ASO) drugs rely on immunohistochemistry (IHC) and/or conjugated molecules, which lack sufficient sensitivity, specificity, and resolution to fully investigate their biodistribution. Our aim was to demonstrate the qualitative and quan...

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Detalles Bibliográficos
Autores principales: Spencer-Dene, Bradley, Mukherjee, Prabuddha, Alex, Aneesh, Bera, Kajari, Tseng, Wei-Ju, Shi, Jindou, Chaney, Eric J., Spillman, Darold R., Marjanovic, Marina, Miranda, Elena, Boppart, Stephen A., Hood, Steve R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578491/
https://www.ncbi.nlm.nih.gov/pubmed/37460153
http://dx.doi.org/10.1261/rna.079699.123

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