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Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis

A potential direct correlation between systemic inflammation and physiological aging has been suggested, along with whether there is a higher expression of inflammatory markers in otherwise healthy older adults. Cross-sectional data were extracted from the publicly available 2016 Health and Retireme...

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Autores principales: Kalair, Attiya, Pavan, Matilde, Alpert, Naomi, Ghaffari, Saghi, Taioli, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578595/
https://www.ncbi.nlm.nih.gov/pubmed/37844090
http://dx.doi.org/10.1371/journal.pone.0293027
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author Kalair, Attiya
Pavan, Matilde
Alpert, Naomi
Ghaffari, Saghi
Taioli, Emanuela
author_facet Kalair, Attiya
Pavan, Matilde
Alpert, Naomi
Ghaffari, Saghi
Taioli, Emanuela
author_sort Kalair, Attiya
collection PubMed
description A potential direct correlation between systemic inflammation and physiological aging has been suggested, along with whether there is a higher expression of inflammatory markers in otherwise healthy older adults. Cross-sectional data were extracted from the publicly available 2016 Health and Retirement Survey, a nationally representative survey of older adults in the United States. A subset of participants (n = 9934) consented to a blood draw at the time of recruitment and were measured for high sensitivity C-reactive protein (hs-CRP), Interleukin (IL-6, IL-10, IL-1RA), soluble tumor necrosis factor receptor (sTNFR-1) and transforming growth factor beta 1 (TGF-β1). We included 9,188 participants, representative of 83,939,225 nationally. After adjusting for sex and the number of comorbidities, there remained a significant positive correlation between age and ln (log adjusted) IL-6, and ln sTNFR-1, and a significant inverse correlation between age and ln IL-1RA, ln TGF-β1, and ln hs-CRP. Among the subset of participants who reported none of the available comorbidities (n = 971), there remained an independent correlation of age with ln IL-6 and ln sTNFR-1. After adjusting for age, sex, and number of reported comorbidities, there was a statistically significant correlation between increased ln IL-6, ln IL-10, ln sTNFR-1, and ln hs-CRP with death. This study highlights the existence of a correlation between serum biomarkers of inflammation and aging, not only in the whole population, but also in the smaller subset who reported no comorbidities, confirming the existence of a presence of low-grade inflammation in aging, even in healthy elders. We also highlight the existence of a correlation between inflammatory markers and overall mortality. Future studies should address a possible threshold of systemic inflammation where mortality significantly increases, as well as explore the effectiveness of anti-inflammatory treatments on morbidity and mortality in healthy aging subjects.
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spelling pubmed-105785952023-10-17 Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis Kalair, Attiya Pavan, Matilde Alpert, Naomi Ghaffari, Saghi Taioli, Emanuela PLoS One Research Article A potential direct correlation between systemic inflammation and physiological aging has been suggested, along with whether there is a higher expression of inflammatory markers in otherwise healthy older adults. Cross-sectional data were extracted from the publicly available 2016 Health and Retirement Survey, a nationally representative survey of older adults in the United States. A subset of participants (n = 9934) consented to a blood draw at the time of recruitment and were measured for high sensitivity C-reactive protein (hs-CRP), Interleukin (IL-6, IL-10, IL-1RA), soluble tumor necrosis factor receptor (sTNFR-1) and transforming growth factor beta 1 (TGF-β1). We included 9,188 participants, representative of 83,939,225 nationally. After adjusting for sex and the number of comorbidities, there remained a significant positive correlation between age and ln (log adjusted) IL-6, and ln sTNFR-1, and a significant inverse correlation between age and ln IL-1RA, ln TGF-β1, and ln hs-CRP. Among the subset of participants who reported none of the available comorbidities (n = 971), there remained an independent correlation of age with ln IL-6 and ln sTNFR-1. After adjusting for age, sex, and number of reported comorbidities, there was a statistically significant correlation between increased ln IL-6, ln IL-10, ln sTNFR-1, and ln hs-CRP with death. This study highlights the existence of a correlation between serum biomarkers of inflammation and aging, not only in the whole population, but also in the smaller subset who reported no comorbidities, confirming the existence of a presence of low-grade inflammation in aging, even in healthy elders. We also highlight the existence of a correlation between inflammatory markers and overall mortality. Future studies should address a possible threshold of systemic inflammation where mortality significantly increases, as well as explore the effectiveness of anti-inflammatory treatments on morbidity and mortality in healthy aging subjects. Public Library of Science 2023-10-16 /pmc/articles/PMC10578595/ /pubmed/37844090 http://dx.doi.org/10.1371/journal.pone.0293027 Text en © 2023 Kalair et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kalair, Attiya
Pavan, Matilde
Alpert, Naomi
Ghaffari, Saghi
Taioli, Emanuela
Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
title Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
title_full Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
title_fullStr Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
title_full_unstemmed Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
title_short Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
title_sort blood inflammatory markers and mortality in the us population: a health and retirement survey (hrs) analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578595/
https://www.ncbi.nlm.nih.gov/pubmed/37844090
http://dx.doi.org/10.1371/journal.pone.0293027
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