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Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico
Older people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but there are few studies among them, particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in older Hispanics by c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578661/ https://www.ncbi.nlm.nih.gov/pubmed/37832052 http://dx.doi.org/10.1097/MD.0000000000035458 |
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author | Medrano, Belinda A. Lee, Miryoung Gemeinhardt, Gretchen Rodríguez-Herrera, Javier E. García-Viveros, Moncerrato Restrepo, Blanca I. |
author_facet | Medrano, Belinda A. Lee, Miryoung Gemeinhardt, Gretchen Rodríguez-Herrera, Javier E. García-Viveros, Moncerrato Restrepo, Blanca I. |
author_sort | Medrano, Belinda A. |
collection | PubMed |
description | Older people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but there are few studies among them, particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in older Hispanics by conducting a cross-sectional study of TB surveillance data from Tamaulipas, Mexico (2006–2013; n = 8381). Multivariable logistic regressions were assessed for older adults (OA ≥65 years) when compared to young (YA, 18–39 years) and middle-aged adults (40–64 years). We found that the OA had features associated with a less complicated TB (e.g., lower prevalence of extra-pulmonary TB and less likely to abandon treatment or have drug resistant TB), and yet, were more likely to die during TB treatment (adj-OR 3.9, 95% 2.5, 5.25). Among the OA, excess alcohol use and low body mass index increased their odds of death during TB treatment, while a higher number of reported contacts (social support) was protective. Diabetes was not associated with adverse outcomes in OA. Although older age is a predictor of death during TB disease, OA are not prioritized by the World Health Organization for latent TB infection screening and treatment during contact investigations. With safer, short-course latent TB infection treatment available, we propose the inclusion of OA as a high-risk group in latent TB management guidelines. |
format | Online Article Text |
id | pubmed-10578661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105786612023-10-17 Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico Medrano, Belinda A. Lee, Miryoung Gemeinhardt, Gretchen Rodríguez-Herrera, Javier E. García-Viveros, Moncerrato Restrepo, Blanca I. Medicine (Baltimore) Observational Study Older people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but there are few studies among them, particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in older Hispanics by conducting a cross-sectional study of TB surveillance data from Tamaulipas, Mexico (2006–2013; n = 8381). Multivariable logistic regressions were assessed for older adults (OA ≥65 years) when compared to young (YA, 18–39 years) and middle-aged adults (40–64 years). We found that the OA had features associated with a less complicated TB (e.g., lower prevalence of extra-pulmonary TB and less likely to abandon treatment or have drug resistant TB), and yet, were more likely to die during TB treatment (adj-OR 3.9, 95% 2.5, 5.25). Among the OA, excess alcohol use and low body mass index increased their odds of death during TB treatment, while a higher number of reported contacts (social support) was protective. Diabetes was not associated with adverse outcomes in OA. Although older age is a predictor of death during TB disease, OA are not prioritized by the World Health Organization for latent TB infection screening and treatment during contact investigations. With safer, short-course latent TB infection treatment available, we propose the inclusion of OA as a high-risk group in latent TB management guidelines. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578661/ /pubmed/37832052 http://dx.doi.org/10.1097/MD.0000000000035458 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Observational Study Medrano, Belinda A. Lee, Miryoung Gemeinhardt, Gretchen Rodríguez-Herrera, Javier E. García-Viveros, Moncerrato Restrepo, Blanca I. Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico |
title | Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico |
title_full | Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico |
title_fullStr | Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico |
title_full_unstemmed | Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico |
title_short | Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico |
title_sort | tuberculosis presentation and outcomes in older hispanic adults from tamaulipas, mexico |
topic | Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578661/ https://www.ncbi.nlm.nih.gov/pubmed/37832052 http://dx.doi.org/10.1097/MD.0000000000035458 |
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