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Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model

The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2...

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Autores principales: Park, Jong Sung, Kim, Do-Hoon, Kim, Byong-Kyu, Park, Kyeong-Hyeon, Park, Dong Ho, Hwang, Yang Ha, Kim, Chang-Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578724/
https://www.ncbi.nlm.nih.gov/pubmed/37832124
http://dx.doi.org/10.1097/MD.0000000000035548
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author Park, Jong Sung
Kim, Do-Hoon
Kim, Byong-Kyu
Park, Kyeong-Hyeon
Park, Dong Ho
Hwang, Yang Ha
Kim, Chang-Yeon
author_facet Park, Jong Sung
Kim, Do-Hoon
Kim, Byong-Kyu
Park, Kyeong-Hyeon
Park, Dong Ho
Hwang, Yang Ha
Kim, Chang-Yeon
author_sort Park, Jong Sung
collection PubMed
description The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2011 and 2020 and those with 3 or more tests for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were included. The patients were divided into those with a coefficient of variation (CV) of TC higher than the mean (high-CV group) and those with a lower CV of TC (low-CV group). Moreover, 1:1 propensity score matching was conducted based on demographic variables. Cataract, dementia, or osteoporosis was defined as having a diagnostic, drug, or surgical code based on the cohort definition. Of the 12,882 patients, cataracts, dementia, and osteoporosis were developed in 525 (4.1%), 198 (1.5%), and 438 (3.4%) patients, respectively. The stratified Cox proportional hazards model showed that the incidences of cataracts and osteoporosis were 1.38 and 1.45 times greater in the high-CV group than in the low-CV group, respectively. Our study revealed that TC variability is associated with developing cataracts and osteoporosis.
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spelling pubmed-105787242023-10-17 Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model Park, Jong Sung Kim, Do-Hoon Kim, Byong-Kyu Park, Kyeong-Hyeon Park, Dong Ho Hwang, Yang Ha Kim, Chang-Yeon Medicine (Baltimore) 4600 The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2011 and 2020 and those with 3 or more tests for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were included. The patients were divided into those with a coefficient of variation (CV) of TC higher than the mean (high-CV group) and those with a lower CV of TC (low-CV group). Moreover, 1:1 propensity score matching was conducted based on demographic variables. Cataract, dementia, or osteoporosis was defined as having a diagnostic, drug, or surgical code based on the cohort definition. Of the 12,882 patients, cataracts, dementia, and osteoporosis were developed in 525 (4.1%), 198 (1.5%), and 438 (3.4%) patients, respectively. The stratified Cox proportional hazards model showed that the incidences of cataracts and osteoporosis were 1.38 and 1.45 times greater in the high-CV group than in the low-CV group, respectively. Our study revealed that TC variability is associated with developing cataracts and osteoporosis. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578724/ /pubmed/37832124 http://dx.doi.org/10.1097/MD.0000000000035548 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4600
Park, Jong Sung
Kim, Do-Hoon
Kim, Byong-Kyu
Park, Kyeong-Hyeon
Park, Dong Ho
Hwang, Yang Ha
Kim, Chang-Yeon
Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
title Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
title_full Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
title_fullStr Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
title_full_unstemmed Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
title_short Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
title_sort effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: a study using a common data model
topic 4600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578724/
https://www.ncbi.nlm.nih.gov/pubmed/37832124
http://dx.doi.org/10.1097/MD.0000000000035548
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