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Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model
The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578724/ https://www.ncbi.nlm.nih.gov/pubmed/37832124 http://dx.doi.org/10.1097/MD.0000000000035548 |
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author | Park, Jong Sung Kim, Do-Hoon Kim, Byong-Kyu Park, Kyeong-Hyeon Park, Dong Ho Hwang, Yang Ha Kim, Chang-Yeon |
author_facet | Park, Jong Sung Kim, Do-Hoon Kim, Byong-Kyu Park, Kyeong-Hyeon Park, Dong Ho Hwang, Yang Ha Kim, Chang-Yeon |
author_sort | Park, Jong Sung |
collection | PubMed |
description | The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2011 and 2020 and those with 3 or more tests for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were included. The patients were divided into those with a coefficient of variation (CV) of TC higher than the mean (high-CV group) and those with a lower CV of TC (low-CV group). Moreover, 1:1 propensity score matching was conducted based on demographic variables. Cataract, dementia, or osteoporosis was defined as having a diagnostic, drug, or surgical code based on the cohort definition. Of the 12,882 patients, cataracts, dementia, and osteoporosis were developed in 525 (4.1%), 198 (1.5%), and 438 (3.4%) patients, respectively. The stratified Cox proportional hazards model showed that the incidences of cataracts and osteoporosis were 1.38 and 1.45 times greater in the high-CV group than in the low-CV group, respectively. Our study revealed that TC variability is associated with developing cataracts and osteoporosis. |
format | Online Article Text |
id | pubmed-10578724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105787242023-10-17 Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model Park, Jong Sung Kim, Do-Hoon Kim, Byong-Kyu Park, Kyeong-Hyeon Park, Dong Ho Hwang, Yang Ha Kim, Chang-Yeon Medicine (Baltimore) 4600 The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2011 and 2020 and those with 3 or more tests for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were included. The patients were divided into those with a coefficient of variation (CV) of TC higher than the mean (high-CV group) and those with a lower CV of TC (low-CV group). Moreover, 1:1 propensity score matching was conducted based on demographic variables. Cataract, dementia, or osteoporosis was defined as having a diagnostic, drug, or surgical code based on the cohort definition. Of the 12,882 patients, cataracts, dementia, and osteoporosis were developed in 525 (4.1%), 198 (1.5%), and 438 (3.4%) patients, respectively. The stratified Cox proportional hazards model showed that the incidences of cataracts and osteoporosis were 1.38 and 1.45 times greater in the high-CV group than in the low-CV group, respectively. Our study revealed that TC variability is associated with developing cataracts and osteoporosis. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578724/ /pubmed/37832124 http://dx.doi.org/10.1097/MD.0000000000035548 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 4600 Park, Jong Sung Kim, Do-Hoon Kim, Byong-Kyu Park, Kyeong-Hyeon Park, Dong Ho Hwang, Yang Ha Kim, Chang-Yeon Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model |
title | Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model |
title_full | Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model |
title_fullStr | Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model |
title_full_unstemmed | Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model |
title_short | Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model |
title_sort | effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: a study using a common data model |
topic | 4600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578724/ https://www.ncbi.nlm.nih.gov/pubmed/37832124 http://dx.doi.org/10.1097/MD.0000000000035548 |
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