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Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis?
Neutrophil gelatinase-associated lipocalin (NGAL, also known as lipocalin-2) is an acute-phase protein expressed in many tissues and plays a role in cell proliferation, regulation, and epithelial-mesenchymal transformation. Therefore, this study aimed to investigate serum NGAL levels and endometriom...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578740/ https://www.ncbi.nlm.nih.gov/pubmed/37832065 http://dx.doi.org/10.1097/MD.0000000000035539 |
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author | Guney, Gurhan Taskin, Mine Islimye Laganà, Antonio Simone Tolu, Ezgi Aslan, Figen Hismiogullari, Adnan Adil Kaya, Cihan |
author_facet | Guney, Gurhan Taskin, Mine Islimye Laganà, Antonio Simone Tolu, Ezgi Aslan, Figen Hismiogullari, Adnan Adil Kaya, Cihan |
author_sort | Guney, Gurhan |
collection | PubMed |
description | Neutrophil gelatinase-associated lipocalin (NGAL, also known as lipocalin-2) is an acute-phase protein expressed in many tissues and plays a role in cell proliferation, regulation, and epithelial-mesenchymal transformation. Therefore, this study aimed to investigate serum NGAL levels and endometrioma tissue expression in women with endometriosis. This cross-sectional study was conducted at a university hospital. The endometrioma group included 36 women who underwent ovarian cystectomy for endometrioma, which was compared with a control group (n = 36) of women who underwent ovarian cystectomy due to benign persistent cysts (follicle cyst, theca lutein cyst, and serous cystadenoma). NGAL levels were analyzed using both serum enzyme-linked immunosorbent assay analysis and immunohistochemical tissue staining. Serum C-reactive protein and CA-125 levels were also evaluated. NGAL serum levels were significantly higher in the endometrioma group than in the control group (P < .05). C-reactive protein and CA-125 levels were also significantly higher in the endometrioma group (P < .05) and were correlated with NGAL levels. Immunohistochemical staining for NGAL was also higher in the endometrioma group (P < .001). NGAL may be considered a potential noninvasive biomarker of endometriosis. |
format | Online Article Text |
id | pubmed-10578740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105787402023-10-17 Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? Guney, Gurhan Taskin, Mine Islimye Laganà, Antonio Simone Tolu, Ezgi Aslan, Figen Hismiogullari, Adnan Adil Kaya, Cihan Medicine (Baltimore) Research Article: Observational Study Neutrophil gelatinase-associated lipocalin (NGAL, also known as lipocalin-2) is an acute-phase protein expressed in many tissues and plays a role in cell proliferation, regulation, and epithelial-mesenchymal transformation. Therefore, this study aimed to investigate serum NGAL levels and endometrioma tissue expression in women with endometriosis. This cross-sectional study was conducted at a university hospital. The endometrioma group included 36 women who underwent ovarian cystectomy for endometrioma, which was compared with a control group (n = 36) of women who underwent ovarian cystectomy due to benign persistent cysts (follicle cyst, theca lutein cyst, and serous cystadenoma). NGAL levels were analyzed using both serum enzyme-linked immunosorbent assay analysis and immunohistochemical tissue staining. Serum C-reactive protein and CA-125 levels were also evaluated. NGAL serum levels were significantly higher in the endometrioma group than in the control group (P < .05). C-reactive protein and CA-125 levels were also significantly higher in the endometrioma group (P < .05) and were correlated with NGAL levels. Immunohistochemical staining for NGAL was also higher in the endometrioma group (P < .001). NGAL may be considered a potential noninvasive biomarker of endometriosis. Lippincott Williams & Wilkins 2023-10-13 /pmc/articles/PMC10578740/ /pubmed/37832065 http://dx.doi.org/10.1097/MD.0000000000035539 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article: Observational Study Guney, Gurhan Taskin, Mine Islimye Laganà, Antonio Simone Tolu, Ezgi Aslan, Figen Hismiogullari, Adnan Adil Kaya, Cihan Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? |
title | Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? |
title_full | Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? |
title_fullStr | Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? |
title_full_unstemmed | Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? |
title_short | Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis? |
title_sort | neutrophil gelatinase-associated lipocalin serum level: a potential noninvasive biomarker of endometriosis? |
topic | Research Article: Observational Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578740/ https://www.ncbi.nlm.nih.gov/pubmed/37832065 http://dx.doi.org/10.1097/MD.0000000000035539 |
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