Interference with the HNF4-dependent gene regulatory network diminishes endoplasmic reticulum stress in hepatocytes

BACKGROUND: In all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet, ER stress in the liver is uniquely accompanied by the suppression of metabolic gene...

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Detalles Bibliográficos
Autores principales: Shah, Anit, Huck, Ian, Duncan, Kaylia, Gansemer, Erica R., Liu, Kaihua, Adajar, Reed C., Apte, Udayan, Stamnes, Mark A., Rutkowski, D. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578741/
https://www.ncbi.nlm.nih.gov/pubmed/37820274
http://dx.doi.org/10.1097/HC9.0000000000000278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578741/
https://www.ncbi.nlm.nih.gov/pubmed/37820274
http://dx.doi.org/10.1097/HC9.0000000000000278

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